Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia.
Schizophrenia is a sophisticated mental disability which has affected nearly1.1% of people all over the world. According to recent researches, the key proteins triggered in the immune system are cytokines which might also be taking part in the pathogenesis of schizophrenia. The aim of this study was...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ferdowsi University of Mashhad
2014-01-01
|
| Series: | Journal of Cell and Molecular Research |
| Subjects: | |
| Online Access: | https://jcmr.um.ac.ir/article_27537_c6399548fdce90587896908a2c5d638e.pdf |
| _version_ | 1818976060119711744 |
|---|---|
| author | Dor Mohammad kordi Tamandani Azizoallah Mojahed Maryam Najafi |
| author_facet | Dor Mohammad kordi Tamandani Azizoallah Mojahed Maryam Najafi |
| author_sort | Dor Mohammad kordi Tamandani |
| collection | DOAJ |
| description | Schizophrenia is a sophisticated mental disability which has affected nearly1.1% of people all over the world. According to recent researches, the key proteins triggered in the immune system are cytokines which might also be taking part in the pathogenesis of schizophrenia. The aim of this study was to evaluate the relationship between the -1082G/A and +874T/A polymorphisms of IL-10 and IFN-γ genes, respectively, in patients with schizophrenia. Materials and Methods: Total of 94 schizophrenic patients and 97 individuals as control samples were enrolled in this study. All samples were genotyped by amplification mutation refractory system-polymerase chain reaction (ARMS PCR) for candidate SNPs in IFN-γ and IL-10 genes. Results: No significant association was found among various genotypes of IFN-γ and IL-10 in selected SNPs with risk of schizophrenia, As well as there was no significant variation in allelic frequency of IFN-γ and IL-10 genes with the risk of disease. Conclusion: These data suggest that the -1082G/A of IL-10 and +874T/A IFNγ genes are not involved in the development of schizophrenia risk. To validate of this data, suggesting more studies in diverse populations with larger sample size. |
| first_indexed | 2024-12-20T16:05:50Z |
| format | Article |
| id | doaj.art-22c4c85997184eb5bf926bab3e3ae725 |
| institution | Directory Open Access Journal |
| issn | 2008-9147 2717-3364 |
| language | English |
| last_indexed | 2024-12-20T16:05:50Z |
| publishDate | 2014-01-01 |
| publisher | Ferdowsi University of Mashhad |
| record_format | Article |
| series | Journal of Cell and Molecular Research |
| spelling | doaj.art-22c4c85997184eb5bf926bab3e3ae7252022-12-21T19:34:10ZengFerdowsi University of MashhadJournal of Cell and Molecular Research2008-91472717-33642014-01-0162646810.22067/jcmr.v6i2.3458427537Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia.Dor Mohammad kordi Tamandani0Azizoallah Mojahed1Maryam Najafi2University of Sistan BaluchistanUniversity of Sistan BaluchistanUniversity of Sistan BaluchistanSchizophrenia is a sophisticated mental disability which has affected nearly1.1% of people all over the world. According to recent researches, the key proteins triggered in the immune system are cytokines which might also be taking part in the pathogenesis of schizophrenia. The aim of this study was to evaluate the relationship between the -1082G/A and +874T/A polymorphisms of IL-10 and IFN-γ genes, respectively, in patients with schizophrenia. Materials and Methods: Total of 94 schizophrenic patients and 97 individuals as control samples were enrolled in this study. All samples were genotyped by amplification mutation refractory system-polymerase chain reaction (ARMS PCR) for candidate SNPs in IFN-γ and IL-10 genes. Results: No significant association was found among various genotypes of IFN-γ and IL-10 in selected SNPs with risk of schizophrenia, As well as there was no significant variation in allelic frequency of IFN-γ and IL-10 genes with the risk of disease. Conclusion: These data suggest that the -1082G/A of IL-10 and +874T/A IFNγ genes are not involved in the development of schizophrenia risk. To validate of this data, suggesting more studies in diverse populations with larger sample size.https://jcmr.um.ac.ir/article_27537_c6399548fdce90587896908a2c5d638e.pdfschizophreniaifn-γil-10genepolymorphism |
| spellingShingle | Dor Mohammad kordi Tamandani Azizoallah Mojahed Maryam Najafi Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia. Journal of Cell and Molecular Research schizophrenia ifn-γ il-10 gene polymorphism |
| title | Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia. |
| title_full | Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia. |
| title_fullStr | Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia. |
| title_full_unstemmed | Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia. |
| title_short | Analysis of IFN-γ (+874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia. |
| title_sort | analysis of ifn γ 874 a t and il 10 1082 g a genes polymorphisms with risk of schizophrenia |
| topic | schizophrenia ifn-γ il-10 gene polymorphism |
| url | https://jcmr.um.ac.ir/article_27537_c6399548fdce90587896908a2c5d638e.pdf |
| work_keys_str_mv | AT dormohammadkorditamandani analysisofifng874atandil101082gagenespolymorphismswithriskofschizophrenia AT azizoallahmojahed analysisofifng874atandil101082gagenespolymorphismswithriskofschizophrenia AT maryamnajafi analysisofifng874atandil101082gagenespolymorphismswithriskofschizophrenia |