Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups
Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. The study assessed the hepatoprotective potential of ethyl acetate fraction Tamarindus indica leaves (EFTI) during prenatal aluminum chloride exposure. Pregnant rats were di...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023000318 |
| _version_ | 1797798857669607424 |
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| author | Helen Ruth Yusuf Sunday Abraham Musa Abel Nosereme Agbon Ejike Daniel Eze Akeem Ayodeji Okesina Ismail Onanuga Theophilus Pius Victor Archibong Mario Edgar Fernandez Diaz Juma John Ochieng Nicholas Kusiima Bot Yakubu Sunday Ibe Michael Usman |
| author_facet | Helen Ruth Yusuf Sunday Abraham Musa Abel Nosereme Agbon Ejike Daniel Eze Akeem Ayodeji Okesina Ismail Onanuga Theophilus Pius Victor Archibong Mario Edgar Fernandez Diaz Juma John Ochieng Nicholas Kusiima Bot Yakubu Sunday Ibe Michael Usman |
| author_sort | Helen Ruth Yusuf |
| collection | DOAJ |
| description | Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. The study assessed the hepatoprotective potential of ethyl acetate fraction Tamarindus indica leaves (EFTI) during prenatal aluminum chloride exposure. Pregnant rats were divided into 5 groups (n = 4); Group I rats were administered 2 ml kg−1 of distilled water (negative control), Group II rats received only 200 mg kg−1 aluminum chloride (positive control), Group III rats were administered 200 mg kg−1 aluminum chloride and 400 mg kg−1 EFTI, Group IV rats were administered 200 mg kg−1 aluminum chloride and 800 mg kg−1 EFTI, Group V rats were administered 200 mg kg−1 aluminum chloride and 300 mg kg−1 Vit E (comparative control). On postnatal day 1, the pups were euthanized, and liver tissues were harvested for the biochemical study (tissue levels of malondialdehyde, caspase-3, tumor necrosis factor-alpha, aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferases) and the liver histological examination. The administration of EFTI was marked with significant improvement in the tissue levels of malondialdehyde, caspase-3, tumor necrosis factor-alpha, aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferases. There was a marked improvement in histopathological changes associated with prenatal aluminum chloride exposure. In conclusion, the administration of EFTI was protective during prenatal aluminum chloride exposure of the liver in Wistar rats, and is mediated by the anti-lipid peroxidative, antiapoptotic, and anti-inflammatory activity of EFTI. |
| first_indexed | 2024-03-13T04:10:55Z |
| format | Article |
| id | doaj.art-22c527d5996644888765f7ce77d53452 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-13T04:10:55Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-22c527d5996644888765f7ce77d534522023-06-21T06:55:07ZengElsevierToxicology Reports2214-75002023-01-0110376381Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pupsHelen Ruth Yusuf0Sunday Abraham Musa1Abel Nosereme Agbon2Ejike Daniel Eze3Akeem Ayodeji Okesina4Ismail Onanuga5Theophilus Pius6Victor Archibong7Mario Edgar Fernandez Diaz8Juma John Ochieng9Nicholas Kusiima10Bot Yakubu Sunday11Ibe Michael Usman12Department of Human Anatomy, Ahmadu Bello University, Zaria, NigeriaDepartment of Human Anatomy, Ahmadu Bello University, Zaria, NigeriaDepartment of Human Anatomy, Ahmadu Bello University, Zaria, NigeriaPhysiology Department, Kabale University, Kabale, UgandaDepartment of Clinical Medicine and Community Health, University of Rwanda, RwandaDepartment of Human Anatomy, Kampala International University, TanzaniaDepartment of Medical Laboratory, Kampala International University, UgandaDepartment of Human Anatomy, University of Rwanda, RwandaDepartment of Human Anatomy, Kampala International University, UgandaDepartment of Human Anatomy, Kampala International University, UgandaDepartment of Medical Laboratory, Kampala International University, UgandaDepartment of Medical Laboratory, Kampala International University, UgandaDepartment of Human Anatomy, Kampala International University, Uganda; Corresponding author.Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. The study assessed the hepatoprotective potential of ethyl acetate fraction Tamarindus indica leaves (EFTI) during prenatal aluminum chloride exposure. Pregnant rats were divided into 5 groups (n = 4); Group I rats were administered 2 ml kg−1 of distilled water (negative control), Group II rats received only 200 mg kg−1 aluminum chloride (positive control), Group III rats were administered 200 mg kg−1 aluminum chloride and 400 mg kg−1 EFTI, Group IV rats were administered 200 mg kg−1 aluminum chloride and 800 mg kg−1 EFTI, Group V rats were administered 200 mg kg−1 aluminum chloride and 300 mg kg−1 Vit E (comparative control). On postnatal day 1, the pups were euthanized, and liver tissues were harvested for the biochemical study (tissue levels of malondialdehyde, caspase-3, tumor necrosis factor-alpha, aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferases) and the liver histological examination. The administration of EFTI was marked with significant improvement in the tissue levels of malondialdehyde, caspase-3, tumor necrosis factor-alpha, aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferases. There was a marked improvement in histopathological changes associated with prenatal aluminum chloride exposure. In conclusion, the administration of EFTI was protective during prenatal aluminum chloride exposure of the liver in Wistar rats, and is mediated by the anti-lipid peroxidative, antiapoptotic, and anti-inflammatory activity of EFTI.http://www.sciencedirect.com/science/article/pii/S2214750023000318Caspase-3Tumor necrosis factor-alphaMedicinal plantReticular fiberAluminum toxicity |
| spellingShingle | Helen Ruth Yusuf Sunday Abraham Musa Abel Nosereme Agbon Ejike Daniel Eze Akeem Ayodeji Okesina Ismail Onanuga Theophilus Pius Victor Archibong Mario Edgar Fernandez Diaz Juma John Ochieng Nicholas Kusiima Bot Yakubu Sunday Ibe Michael Usman Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups Toxicology Reports Caspase-3 Tumor necrosis factor-alpha Medicinal plant Reticular fiber Aluminum toxicity |
| title | Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups |
| title_full | Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups |
| title_fullStr | Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups |
| title_full_unstemmed | Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups |
| title_short | Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups |
| title_sort | hepatoprotective potential of tamarindus indica following prenatal aluminum exposure in wistar rat pups |
| topic | Caspase-3 Tumor necrosis factor-alpha Medicinal plant Reticular fiber Aluminum toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023000318 |
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