Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive Study
Introduction: Cancer is associated with multiple renal manifestations like Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), proteinuria, and electrolyte imbalance. The reason behind renal dysfunction in cancer patients is multifactorial and can be attributed to underlying cancer and treatmen...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/17475/61635_CE[Ra1]_F(IS)_PF1(DA_SS)_PFA(SS)_PB(DA_SS)_PN(SS).pdf |
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| author | Pideno Ngullie Smita Nath Alpana Raizada Sunil Agarwal |
| author_facet | Pideno Ngullie Smita Nath Alpana Raizada Sunil Agarwal |
| author_sort | Pideno Ngullie |
| collection | DOAJ |
| description | Introduction: Cancer is associated with multiple renal manifestations like Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), proteinuria, and electrolyte imbalance. The reason behind renal dysfunction in cancer patients is multifactorial and can be attributed to underlying cancer and treatment modalities, in addition to co-morbidities surgical procedures and infections.
Aim: To assess the spectrum of renal involvement in cancer patients presenting at a tertiary care hospital.
Materials and Methods: The cross-sectional descriptive study, was conducted in the Department of Medicine of University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India. One hundred consecutive patients referred for nephrology consultation with diagnosed cancer, irrespective of cancer aetiology between the age group of 15-70 years with deranged kidney function test were recruited. Detailed medical and treatment history, including the type of cancer-solid or haematological, cancer status-cured or continuing, treatment given-chemotherapy, radiotherapy or surgery or a combination and associated co-morbidities like diabetes mellitus and hypertension were recorded. Routine investigations and special investigations, including assessment of estimated Glomerular Filtration Rate (eGFR) and estimation of Albumin-Creatinine Ration (ACR) was done. Patients were then segregated, based on their kidney function test into groups with AKI or CKD and underlying cause was valuated. Summary statistics was presented as mean, median or frequency and data analysed using Statistical Package of Social Sciences (SPSS) version 24.0.
Results: The mean age of the study population was 53.73±12.20 years with 63% male and 37% female participants; 87% patients had solid cancers, while 13% had haematological cancers. The median duration, since the diagnosis was seven months and the patients were undergoing chemotherapy, radiotherapy or a combination of both; seven patients had surgery for underlying malignancy and an additional six had received chemotherapy or radiation therapy along with surgery. At the time of recruitment, 78% patients had AKI and 22% patients were diagnosed with CKD. Chemotherapy-induced nephropathy was the most common cause of AKI (n=46). In the CKD group diabetes (n=7) was the most common aetiology.
Conclusion: The kidneys in cancer patients can be involved in a number of ways, as a consequence of the cancer itself, its treatment, superimposed infections or associated co-morbidities. Chemotherapy-induced nephropathy is the most common cause of AKI, whereas, diabetes is the most common cause of CKD in cancer patients. |
| first_indexed | 2024-04-10T00:30:38Z |
| format | Article |
| id | doaj.art-22c6d0d5b8ce487fa960fb9f08935a75 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T00:30:38Z |
| publishDate | 2023-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-22c6d0d5b8ce487fa960fb9f08935a752023-03-15T04:15:43ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-02-01172OC25OC2810.7860/JCDR/2023/61635.17475Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive StudyPideno Ngullie0Smita Nath1Alpana Raizada2Sunil Agarwal3Consultant, Department of Medicine, Eden Medical Centre, Dimapur, Nagaland, India.Assistant Professor, Department of Medicine, University College of Medical Sciences, New Delhi, India.Professor, Department of Medicine, University College of Medical Sciences, New Delhi, India.Ex-Professor, Department of Medicine, University College of Medical Sciences, New Delhi, India.Introduction: Cancer is associated with multiple renal manifestations like Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), proteinuria, and electrolyte imbalance. The reason behind renal dysfunction in cancer patients is multifactorial and can be attributed to underlying cancer and treatment modalities, in addition to co-morbidities surgical procedures and infections. Aim: To assess the spectrum of renal involvement in cancer patients presenting at a tertiary care hospital. Materials and Methods: The cross-sectional descriptive study, was conducted in the Department of Medicine of University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India. One hundred consecutive patients referred for nephrology consultation with diagnosed cancer, irrespective of cancer aetiology between the age group of 15-70 years with deranged kidney function test were recruited. Detailed medical and treatment history, including the type of cancer-solid or haematological, cancer status-cured or continuing, treatment given-chemotherapy, radiotherapy or surgery or a combination and associated co-morbidities like diabetes mellitus and hypertension were recorded. Routine investigations and special investigations, including assessment of estimated Glomerular Filtration Rate (eGFR) and estimation of Albumin-Creatinine Ration (ACR) was done. Patients were then segregated, based on their kidney function test into groups with AKI or CKD and underlying cause was valuated. Summary statistics was presented as mean, median or frequency and data analysed using Statistical Package of Social Sciences (SPSS) version 24.0. Results: The mean age of the study population was 53.73±12.20 years with 63% male and 37% female participants; 87% patients had solid cancers, while 13% had haematological cancers. The median duration, since the diagnosis was seven months and the patients were undergoing chemotherapy, radiotherapy or a combination of both; seven patients had surgery for underlying malignancy and an additional six had received chemotherapy or radiation therapy along with surgery. At the time of recruitment, 78% patients had AKI and 22% patients were diagnosed with CKD. Chemotherapy-induced nephropathy was the most common cause of AKI (n=46). In the CKD group diabetes (n=7) was the most common aetiology. Conclusion: The kidneys in cancer patients can be involved in a number of ways, as a consequence of the cancer itself, its treatment, superimposed infections or associated co-morbidities. Chemotherapy-induced nephropathy is the most common cause of AKI, whereas, diabetes is the most common cause of CKD in cancer patients.https://jcdr.net/articles/PDF/17475/61635_CE[Ra1]_F(IS)_PF1(DA_SS)_PFA(SS)_PB(DA_SS)_PN(SS).pdfacute kidney injurychronic kidney diseasemalignancy |
| spellingShingle | Pideno Ngullie Smita Nath Alpana Raizada Sunil Agarwal Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive Study Journal of Clinical and Diagnostic Research acute kidney injury chronic kidney disease malignancy |
| title | Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive Study |
| title_full | Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive Study |
| title_fullStr | Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive Study |
| title_full_unstemmed | Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive Study |
| title_short | Spectrum of Renal Involvement in Cancer Patients: A Cross-sectional Descriptive Study |
| title_sort | spectrum of renal involvement in cancer patients a cross sectional descriptive study |
| topic | acute kidney injury chronic kidney disease malignancy |
| url | https://jcdr.net/articles/PDF/17475/61635_CE[Ra1]_F(IS)_PF1(DA_SS)_PFA(SS)_PB(DA_SS)_PN(SS).pdf |
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