Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice
Korean pine nut oil (PNO) has been reported to influence weight gain and lipid metabolism. We examined whether PNO replacement in a high-fat diet (HFD) can ameliorate HFD-induced hepatic steatosis. Five-week-old male C57BL mice were fed control diets containing 10% of the energy from fat from PNO or...
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MDPI AG
2016-01-01
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| Series: | Nutrients |
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| Online Access: | http://www.mdpi.com/2072-6643/8/1/59 |
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| author | Soyoung Park Sunhye Shin Yeseo Lim Jae Hoon Shin Je Kyung Seong Sung Nim Han |
| author_facet | Soyoung Park Sunhye Shin Yeseo Lim Jae Hoon Shin Je Kyung Seong Sung Nim Han |
| author_sort | Soyoung Park |
| collection | DOAJ |
| description | Korean pine nut oil (PNO) has been reported to influence weight gain and lipid metabolism. We examined whether PNO replacement in a high-fat diet (HFD) can ameliorate HFD-induced hepatic steatosis. Five-week-old male C57BL mice were fed control diets containing 10% of the energy from fat from PNO or soybean oil (SBO) (PC, SC) or HFDs with 45% of the energy from fat, with 10% from PNO or SBO and 35% from lard (PHFD, SHFD), for 12 weeks. Body weight gain and amount of white adipose tissue were lower in PHFD (10% and 18% lower, respectively) compared with SHFD. Hepatic triacylglycerol (TG) level was significantly lower in PHFD than the SHFD (26% lower). PNO consumption upregulated hepatic ACADL mRNA levels. The hepatic PPARG mRNA level was lower in the PC than in the SC. Expression of the sirtuin (SIRT) 3 protein in white adipose tissue was down-regulated in the SHFD and restored in the PHFD to the level in the lean control mice. SIRT 3 was reported to be upregulated under conditions of caloric restriction (CR) and plays a role in regulating mitochondrial function. PNO consumption resulted in lower body fat and hepatic TG accumulation in HFD-induced obesity, which seemed to be associated with the CR-mimetic response. |
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| id | doaj.art-22c88a5752474022851a504014cc42dd |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-13T18:32:01Z |
| publishDate | 2016-01-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-22c88a5752474022851a504014cc42dd2022-12-22T02:35:02ZengMDPI AGNutrients2072-66432016-01-01815910.3390/nu8010059nu8010059Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese MiceSoyoung Park0Sunhye Shin1Yeseo Lim2Jae Hoon Shin3Je Kyung Seong4Sung Nim Han5Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, KoreaDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, KoreaDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, KoreaCollege of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, KoreaCollege of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, KoreaDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, KoreaKorean pine nut oil (PNO) has been reported to influence weight gain and lipid metabolism. We examined whether PNO replacement in a high-fat diet (HFD) can ameliorate HFD-induced hepatic steatosis. Five-week-old male C57BL mice were fed control diets containing 10% of the energy from fat from PNO or soybean oil (SBO) (PC, SC) or HFDs with 45% of the energy from fat, with 10% from PNO or SBO and 35% from lard (PHFD, SHFD), for 12 weeks. Body weight gain and amount of white adipose tissue were lower in PHFD (10% and 18% lower, respectively) compared with SHFD. Hepatic triacylglycerol (TG) level was significantly lower in PHFD than the SHFD (26% lower). PNO consumption upregulated hepatic ACADL mRNA levels. The hepatic PPARG mRNA level was lower in the PC than in the SC. Expression of the sirtuin (SIRT) 3 protein in white adipose tissue was down-regulated in the SHFD and restored in the PHFD to the level in the lean control mice. SIRT 3 was reported to be upregulated under conditions of caloric restriction (CR) and plays a role in regulating mitochondrial function. PNO consumption resulted in lower body fat and hepatic TG accumulation in HFD-induced obesity, which seemed to be associated with the CR-mimetic response.http://www.mdpi.com/2072-6643/8/1/59pine nut oilhigh-fat dietobesityhepatic steatosisSIRT3 |
| spellingShingle | Soyoung Park Sunhye Shin Yeseo Lim Jae Hoon Shin Je Kyung Seong Sung Nim Han Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice Nutrients pine nut oil high-fat diet obesity hepatic steatosis SIRT3 |
| title | Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice |
| title_full | Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice |
| title_fullStr | Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice |
| title_full_unstemmed | Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice |
| title_short | Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice |
| title_sort | korean pine nut oil attenuated hepatic triacylglycerol accumulation in high fat diet induced obese mice |
| topic | pine nut oil high-fat diet obesity hepatic steatosis SIRT3 |
| url | http://www.mdpi.com/2072-6643/8/1/59 |
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