Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection.
Sperm morphology is the best predictor of fertilization potential, and the critical predictive information for supporting assisted reproductive methods selection. Given its important predictive value and the declining reality of semen quality in recent years, the threshold of normal sperm morphology...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4239063?pdf=render |
| _version_ | 1818129994517315584 |
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| author | Bo Li Yefei Ma Jianlei Huang Xifeng Xiao Li Li Chuang Liu Yongqian Shi Dong Wang Xiaohong Wang |
| author_facet | Bo Li Yefei Ma Jianlei Huang Xifeng Xiao Li Li Chuang Liu Yongqian Shi Dong Wang Xiaohong Wang |
| author_sort | Bo Li |
| collection | DOAJ |
| description | Sperm morphology is the best predictor of fertilization potential, and the critical predictive information for supporting assisted reproductive methods selection. Given its important predictive value and the declining reality of semen quality in recent years, the threshold of normal sperm morphology rate (NSMR) is being constantly corrected and controversial, from the 4th edition (14%) to the 5th version (4%). We retrospectively analyzed 4756 cases of infertility patients treated with conventional-IVF(c-IVF) or ICSI, which were divided into three groups according to NSMR: ≥14%, 4%-14% and <4%. Here, we demonstrate that, with decrease in NSMR(≥14%, 4%-14%, <4%), in the c-IVF group, the rate of fertilization, normal fertilization, high-quality embryo, multi-pregnancy and birth weight of twins gradually decreased significantly (P<0.05), while the miscarriage rate was significantly increased (p<0.01) and implantation rate, clinical pregnancy rate, ectopic pregnancy rate, preterm birth rate, live birth rate, sex ratio, and birth weight(Singleton) showed no significant change. In the ICSI group, with decrease in NSMR (≥14%, 4%-14%, <4%), high-quality embryo rate, multi-pregnancy rate and birth weight of twins were gradually decreased significantly (p<0.05), while other parameters had no significant difference. Considering the clinical assisted methods selection, in the NFMR ≥14% group, normal fertilization rate of c-IVF was significantly higher than the ICSI group (P<0.05), in the 4%-14% group, birth weight (twins) of c-IVF were significantly higher than the ICSI group, in the <4% group, miscarriage of IVF was significantly higher than the ICSI group. Therefore, we conclude that NSMR is positively related to embryo reproductive potential, and when NSMR<4% (5th edition), ICSI should be considered first, while the NSMR≥4%, c-IVF assisted reproduction might be preferred. |
| first_indexed | 2024-12-11T07:57:59Z |
| format | Article |
| id | doaj.art-22c99cb655954a8c92d691592a68a43e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T07:57:59Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-22c99cb655954a8c92d691592a68a43e2022-12-22T01:15:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11339210.1371/journal.pone.0113392Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection.Bo LiYefei MaJianlei HuangXifeng XiaoLi LiChuang LiuYongqian ShiDong WangXiaohong WangSperm morphology is the best predictor of fertilization potential, and the critical predictive information for supporting assisted reproductive methods selection. Given its important predictive value and the declining reality of semen quality in recent years, the threshold of normal sperm morphology rate (NSMR) is being constantly corrected and controversial, from the 4th edition (14%) to the 5th version (4%). We retrospectively analyzed 4756 cases of infertility patients treated with conventional-IVF(c-IVF) or ICSI, which were divided into three groups according to NSMR: ≥14%, 4%-14% and <4%. Here, we demonstrate that, with decrease in NSMR(≥14%, 4%-14%, <4%), in the c-IVF group, the rate of fertilization, normal fertilization, high-quality embryo, multi-pregnancy and birth weight of twins gradually decreased significantly (P<0.05), while the miscarriage rate was significantly increased (p<0.01) and implantation rate, clinical pregnancy rate, ectopic pregnancy rate, preterm birth rate, live birth rate, sex ratio, and birth weight(Singleton) showed no significant change. In the ICSI group, with decrease in NSMR (≥14%, 4%-14%, <4%), high-quality embryo rate, multi-pregnancy rate and birth weight of twins were gradually decreased significantly (p<0.05), while other parameters had no significant difference. Considering the clinical assisted methods selection, in the NFMR ≥14% group, normal fertilization rate of c-IVF was significantly higher than the ICSI group (P<0.05), in the 4%-14% group, birth weight (twins) of c-IVF were significantly higher than the ICSI group, in the <4% group, miscarriage of IVF was significantly higher than the ICSI group. Therefore, we conclude that NSMR is positively related to embryo reproductive potential, and when NSMR<4% (5th edition), ICSI should be considered first, while the NSMR≥4%, c-IVF assisted reproduction might be preferred.http://europepmc.org/articles/PMC4239063?pdf=render |
| spellingShingle | Bo Li Yefei Ma Jianlei Huang Xifeng Xiao Li Li Chuang Liu Yongqian Shi Dong Wang Xiaohong Wang Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection. PLoS ONE |
| title | Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection. |
| title_full | Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection. |
| title_fullStr | Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection. |
| title_full_unstemmed | Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection. |
| title_short | Probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection. |
| title_sort | probing the effect of human normal sperm morphology rate on cycle outcomes and assisted reproductive methods selection |
| url | http://europepmc.org/articles/PMC4239063?pdf=render |
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