Vitamin D3 enhances the response to cisplatin in bladder cancer through VDR and TAp73 signaling crosstalk

Vitamin D3 enhances the response to cisplatin in bladder cancer through VDR and TAp73 signaling crosstalk

Abstract Background Vitamin D3 (VitD) deficiency is linked to increased incidence and worse survival in bladder cancer (BCa). In addition to cystectomy, patients are treated with cisplatin‐based chemotherapy, however 30%‐50% of patients do not benefit from this treatment. The effects of VitD deficie...

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Bibliographic Details
Main Authors: Brittany L. Bunch, Yingyu Ma, Kristopher Attwood, Lauren Amable, Wei Luo, Carl Morrison, Khurshid A. Guru, Anna Woloszynska‐Read, Pamela A. Hershberger, Donald L. Trump, Candace S. Johnson
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Cancer Medicine
Subjects:
bladder cancer
cisplatin
TAp73
VDR
vitamin D3
Online Access:https://doi.org/10.1002/cam4.2119

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