High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish.
Though lubricant emulsions have been widely used in many industrial processes, various human health hazards have been reported. Conducting a systematic toxicity study on emulsions is difficult since emulsions contain multiple chemical compounds, and hydrophobic compounds form complex emulsion partic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6249010?pdf=render |
| _version_ | 1818059538514837504 |
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| author | Jae-Hoon Han Sang-Kyu Jung |
| author_facet | Jae-Hoon Han Sang-Kyu Jung |
| author_sort | Jae-Hoon Han |
| collection | DOAJ |
| description | Though lubricant emulsions have been widely used in many industrial processes, various human health hazards have been reported. Conducting a systematic toxicity study on emulsions is difficult since emulsions contain multiple chemical compounds, and hydrophobic compounds form complex emulsion particles via surfactants. For a quantitative toxicity study, we developed a high-throughput imaging system using zebrafish and conducted a large scale in vivo toxicity assay of lubricant emulsion and their common ingredients. By computing the locomotion activity of zebrafish from captured time-lapse images, we could quantify the degree of relative toxicity of 29 chemicals. The changes in the locomotion activity over time were observed to vary significantly depending on emulsions, indicating that the degree of toxicity of the commercial products was very diverse. We found that primary ethanolamines were more toxic than secondary or tertiary ethanolamines, and several factors, such as alkyl chain length, EO mole, test concentration, and emulsion particle size, affected toxicity. |
| first_indexed | 2024-12-10T13:18:07Z |
| format | Article |
| id | doaj.art-22cb135a8cad46fbbfc0f5ef4f1e2b1c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T13:18:07Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-22cb135a8cad46fbbfc0f5ef4f1e2b1c2022-12-22T01:47:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020794610.1371/journal.pone.0207946High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish.Jae-Hoon HanSang-Kyu JungThough lubricant emulsions have been widely used in many industrial processes, various human health hazards have been reported. Conducting a systematic toxicity study on emulsions is difficult since emulsions contain multiple chemical compounds, and hydrophobic compounds form complex emulsion particles via surfactants. For a quantitative toxicity study, we developed a high-throughput imaging system using zebrafish and conducted a large scale in vivo toxicity assay of lubricant emulsion and their common ingredients. By computing the locomotion activity of zebrafish from captured time-lapse images, we could quantify the degree of relative toxicity of 29 chemicals. The changes in the locomotion activity over time were observed to vary significantly depending on emulsions, indicating that the degree of toxicity of the commercial products was very diverse. We found that primary ethanolamines were more toxic than secondary or tertiary ethanolamines, and several factors, such as alkyl chain length, EO mole, test concentration, and emulsion particle size, affected toxicity.http://europepmc.org/articles/PMC6249010?pdf=render |
| spellingShingle | Jae-Hoon Han Sang-Kyu Jung High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish. PLoS ONE |
| title | High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish. |
| title_full | High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish. |
| title_fullStr | High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish. |
| title_full_unstemmed | High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish. |
| title_short | High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish. |
| title_sort | high throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish |
| url | http://europepmc.org/articles/PMC6249010?pdf=render |
| work_keys_str_mv | AT jaehoonhan highthroughputtoxicitystudyoflubricantemulsionsandtheircommoningredientsusingzebrafish AT sangkyujung highthroughputtoxicitystudyoflubricantemulsionsandtheircommoningredientsusingzebrafish |