Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement
There are few reports on short-term changes in renal function after surgical aortic valve replacement, and data are scarce regarding its impact on long-term outcomes. This is a retrospective study of patients who underwent isolated aortic valve replacement between 2009 and 2020 in four medical cente...
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| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/4952 |
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| author | Dror B. Leviner Ely Erez Idit Lavi Walid Saliba Erez Sharoni |
| author_facet | Dror B. Leviner Ely Erez Idit Lavi Walid Saliba Erez Sharoni |
| author_sort | Dror B. Leviner |
| collection | DOAJ |
| description | There are few reports on short-term changes in renal function after surgical aortic valve replacement, and data are scarce regarding its impact on long-term outcomes. This is a retrospective study of patients who underwent isolated aortic valve replacement between 2009 and 2020 in four medical centers. Patients with end-stage renal disease were excluded. Renal function was assessed based on short-term changes. Multivariable regression models were used to identify predictors of improvement/deterioration. Cox proportional hazard models were used to assess survival trends. The study included 2402 patients, with a mean age of 69.3 years and a mean eGFR of 82.3 mL/min/1.73 m<sup>2</sup>. Short-term improvement rates were highest in stage 4 (24.4%) and stage 3 (16.8%) patients. Deterioration rates were highest in stage 1 (38.1%) and stage 2 (34.8%) patients. Deterioration in the chronic kidney disease stage was associated with a higher ten-year mortality (<i>p</i> < 0.001, HR 1.46); an improved stage trended toward improved survival (<i>p</i> = 0.14, HR 0.722). Patients with stage 3 and 4 kidney disease tended to remain stable or improve in the short term after aortic valve replacement while patients at stages 1 and 2 were at increased risk of deteriorating. |
| first_indexed | 2024-03-11T00:24:08Z |
| format | Article |
| id | doaj.art-22cbea3a20ba45e6b623473522404e4d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:08Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-22cbea3a20ba45e6b623473522404e4d2023-11-18T23:07:24ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215495210.3390/jcm12154952Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve ReplacementDror B. Leviner0Ely Erez1Idit Lavi2Walid Saliba3Erez Sharoni4Department of Cardiothoracic Surgery, Carmel Medical Centre, Haifa 3436212, IsraelFaculty of Industrial Engineering and Management, Technion-Israel Institute of Technology, Haifa 3200003, IsraelDepartment of Community Medicine and Epidemiology, Carmel Medical Centre Cardiovascular Centre, Haifa 3436212, IsraelThe Ruth & Baruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525422, IsraelDepartment of Cardiothoracic Surgery, Carmel Medical Centre, Haifa 3436212, IsraelThere are few reports on short-term changes in renal function after surgical aortic valve replacement, and data are scarce regarding its impact on long-term outcomes. This is a retrospective study of patients who underwent isolated aortic valve replacement between 2009 and 2020 in four medical centers. Patients with end-stage renal disease were excluded. Renal function was assessed based on short-term changes. Multivariable regression models were used to identify predictors of improvement/deterioration. Cox proportional hazard models were used to assess survival trends. The study included 2402 patients, with a mean age of 69.3 years and a mean eGFR of 82.3 mL/min/1.73 m<sup>2</sup>. Short-term improvement rates were highest in stage 4 (24.4%) and stage 3 (16.8%) patients. Deterioration rates were highest in stage 1 (38.1%) and stage 2 (34.8%) patients. Deterioration in the chronic kidney disease stage was associated with a higher ten-year mortality (<i>p</i> < 0.001, HR 1.46); an improved stage trended toward improved survival (<i>p</i> = 0.14, HR 0.722). Patients with stage 3 and 4 kidney disease tended to remain stable or improve in the short term after aortic valve replacement while patients at stages 1 and 2 were at increased risk of deteriorating.https://www.mdpi.com/2077-0383/12/15/4952aortic valve replacementrenal function |
| spellingShingle | Dror B. Leviner Ely Erez Idit Lavi Walid Saliba Erez Sharoni Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement Journal of Clinical Medicine aortic valve replacement renal function |
| title | Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement |
| title_full | Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement |
| title_fullStr | Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement |
| title_full_unstemmed | Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement |
| title_short | Predictors and Long-Term Prognostic Significance of Acute Renal Function Change in Patients Who Underwent Surgical Aortic Valve Replacement |
| title_sort | predictors and long term prognostic significance of acute renal function change in patients who underwent surgical aortic valve replacement |
| topic | aortic valve replacement renal function |
| url | https://www.mdpi.com/2077-0383/12/15/4952 |
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