Modulation of immune response by bacterial lipopolysaccharides
Lipopolysaccharide (LPS) is a molecule that is profusely found on the outer membrane of Gram-negative bacteria and is also a potent stimulator of the immune response. As the main molecule on the bacterial surface, is also the most biologically active. The immune response of the host is activated by...
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| Format: | Article |
| Language: | English |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2016-08-01
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| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/207 |
| _version_ | 1797715218247188480 |
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| author | Gustavo Aldapa-Vega Rodolfo Pastelín-Palacios Armando Isibasi Mario A. Moreno-Eutimio Constantino López-Macías |
| author_facet | Gustavo Aldapa-Vega Rodolfo Pastelín-Palacios Armando Isibasi Mario A. Moreno-Eutimio Constantino López-Macías |
| author_sort | Gustavo Aldapa-Vega |
| collection | DOAJ |
| description | Lipopolysaccharide (LPS) is a molecule that is profusely found on the outer membrane of Gram-negative bacteria and is also a potent stimulator of the immune response. As the main molecule on the bacterial surface, is also the most biologically active. The immune response of the host is activated by the recognition of LPS through Toll-like receptor 4 (TLR4) and this receptor-ligand interaction is closely linked to LPS structure. Microorganisms have evolved systems to control the expression and structure of LPS, producing structural variants that are used for modulating the host immune responses during infection. Examples of this include Helicobacter pylori, Francisella tularensis, Chlamydia trachomatis and Salmonella spp. High concentrations of LPS can cause fever, increased heart rate and lead to septic shock and death. However, at relatively low concentrations some LPS are highly active immunomodulators, which can induce non-specific resistance to invading microorganisms. The elucidation of the molecular and cellular mechanisms involved in the recognition of LPS and its structural variants has been fundamental to understand inflammation and is currently a pivotal field of research to understand the innate immune response, inflammation, the complex host-pathogen relationship and has important implications for the rational development of new immunomodulators and adjuvants. |
| first_indexed | 2024-03-12T08:03:40Z |
| format | Article |
| id | doaj.art-22cc0d7681d342d2b8f424976f03f81a |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T08:03:40Z |
| publishDate | 2016-08-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-22cc0d7681d342d2b8f424976f03f81a2023-09-02T19:42:41ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902016-08-0163329330210.29262/ram.v63i3.207147Modulation of immune response by bacterial lipopolysaccharidesGustavo Aldapa-Vega0Rodolfo Pastelín-Palacios1Armando Isibasi2Mario A. Moreno-Eutimio3Constantino López-Macías4Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Unidad de Investigación Médica en Inmunoquímica, Ciudad de MéxicoUniversidad Nacional Autónoma de México, Facultad de Química, Departamento de Biología, Ciudad de MéxicoInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Unidad de Investigación Médica en Inmunoquímica, Ciudad de MéxicoSecretaría de Salud, Hospital Juárez de México, Unidad de Investigación, Unidad de investigación de inmunidad e inflamación, Ciudad de MéxicoInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Unidad de Investigación Médica en Inmunoquímica, Ciudad de MéxicoLipopolysaccharide (LPS) is a molecule that is profusely found on the outer membrane of Gram-negative bacteria and is also a potent stimulator of the immune response. As the main molecule on the bacterial surface, is also the most biologically active. The immune response of the host is activated by the recognition of LPS through Toll-like receptor 4 (TLR4) and this receptor-ligand interaction is closely linked to LPS structure. Microorganisms have evolved systems to control the expression and structure of LPS, producing structural variants that are used for modulating the host immune responses during infection. Examples of this include Helicobacter pylori, Francisella tularensis, Chlamydia trachomatis and Salmonella spp. High concentrations of LPS can cause fever, increased heart rate and lead to septic shock and death. However, at relatively low concentrations some LPS are highly active immunomodulators, which can induce non-specific resistance to invading microorganisms. The elucidation of the molecular and cellular mechanisms involved in the recognition of LPS and its structural variants has been fundamental to understand inflammation and is currently a pivotal field of research to understand the innate immune response, inflammation, the complex host-pathogen relationship and has important implications for the rational development of new immunomodulators and adjuvants.http://revistaalergia.mx/ojs/index.php/ram/article/view/207LipopolisacáridoReceptor tipo toll 4Inmunomodulación |
| spellingShingle | Gustavo Aldapa-Vega Rodolfo Pastelín-Palacios Armando Isibasi Mario A. Moreno-Eutimio Constantino López-Macías Modulation of immune response by bacterial lipopolysaccharides Revista Alergia México Lipopolisacárido Receptor tipo toll 4 Inmunomodulación |
| title | Modulation of immune response by bacterial lipopolysaccharides |
| title_full | Modulation of immune response by bacterial lipopolysaccharides |
| title_fullStr | Modulation of immune response by bacterial lipopolysaccharides |
| title_full_unstemmed | Modulation of immune response by bacterial lipopolysaccharides |
| title_short | Modulation of immune response by bacterial lipopolysaccharides |
| title_sort | modulation of immune response by bacterial lipopolysaccharides |
| topic | Lipopolisacárido Receptor tipo toll 4 Inmunomodulación |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/207 |
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