Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes
Parasitic worms (helminths) developed various immunoregulatory mechanisms to counteract the immune system of their host. The increasing identification and characterization of helminth-derived factors with strong immune modulatory activity provides novel insights into immune escape strategies of helm...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.572865/full |
| _version_ | 1811323922778423296 |
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| author | Marie Wiedemann David Voehringer |
| author_facet | Marie Wiedemann David Voehringer |
| author_sort | Marie Wiedemann |
| collection | DOAJ |
| description | Parasitic worms (helminths) developed various immunoregulatory mechanisms to counteract the immune system of their host. The increasing identification and characterization of helminth-derived factors with strong immune modulatory activity provides novel insights into immune escape strategies of helminths. Such factors might be good targets to enhance anti-helminthic immune responses. In addition, immunosuppressive helminth-derived factors could be useful to develop new therapeutic strategies for treatment of chronic inflammatory conditions. This review will take an in depth look at the effects of immunomodulatory molecules produced by different helminths with a focus on schistosomes and mouse models of hookworm infections. |
| first_indexed | 2024-04-13T14:04:05Z |
| format | Article |
| id | doaj.art-22cc24036b0a49f58e25806d0e1e1b68 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T14:04:05Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-22cc24036b0a49f58e25806d0e1e1b682022-12-22T02:43:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.572865572865Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and SchistosomesMarie WiedemannDavid VoehringerParasitic worms (helminths) developed various immunoregulatory mechanisms to counteract the immune system of their host. The increasing identification and characterization of helminth-derived factors with strong immune modulatory activity provides novel insights into immune escape strategies of helminths. Such factors might be good targets to enhance anti-helminthic immune responses. In addition, immunosuppressive helminth-derived factors could be useful to develop new therapeutic strategies for treatment of chronic inflammatory conditions. This review will take an in depth look at the effects of immunomodulatory molecules produced by different helminths with a focus on schistosomes and mouse models of hookworm infections.https://www.frontiersin.org/article/10.3389/fimmu.2020.572865/fullnematodetrematodeimmunomodulationtype 2 immunityparasitesschistosomes |
| spellingShingle | Marie Wiedemann David Voehringer Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes Frontiers in Immunology nematode trematode immunomodulation type 2 immunity parasites schistosomes |
| title | Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes |
| title_full | Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes |
| title_fullStr | Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes |
| title_full_unstemmed | Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes |
| title_short | Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes |
| title_sort | immunomodulation and immune escape strategies of gastrointestinal helminths and schistosomes |
| topic | nematode trematode immunomodulation type 2 immunity parasites schistosomes |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.572865/full |
| work_keys_str_mv | AT mariewiedemann immunomodulationandimmuneescapestrategiesofgastrointestinalhelminthsandschistosomes AT davidvoehringer immunomodulationandimmuneescapestrategiesofgastrointestinalhelminthsandschistosomes |