Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study
The global pandemic of obesity and the increasing incidence of chronic respiratory diseases are growing health concerns. The association between obesity and pulmonary function is uncertain. Therefore, this study aimed to explore associations between changes in lung function and obesity-related indic...
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MDPI AG
2021-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/4055 |
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| author | Yu-En Hsu Szu-Chia Chen Jiun-Hung Geng Da-Wei Wu Pei-Yu Wu Jiun-Chi Huang |
| author_facet | Yu-En Hsu Szu-Chia Chen Jiun-Hung Geng Da-Wei Wu Pei-Yu Wu Jiun-Chi Huang |
| author_sort | Yu-En Hsu |
| collection | DOAJ |
| description | The global pandemic of obesity and the increasing incidence of chronic respiratory diseases are growing health concerns. The association between obesity and pulmonary function is uncertain. Therefore, this study aimed to explore associations between changes in lung function and obesity-related indices in a large longitudinal study. A total of 9059 participants with no personal histories of asthma, smoking, bronchitis, or emphysema were enrolled from the Taiwan Biobank and followed for 4 years. Lung function was assessed using spirometry measurements including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). Changes in FEV1/FVC (∆FEV1/FVC) between baseline and follow-up were calculated. The following obesity-related indices were studied: lipid accumulation product (LAP), body roundness index (BRI), conicity index (CI), body adiposity index (BAI), abdominal volume index (AVI), body mass index (BMI), waist–hip ratio (WHR), and waist-to-height ratio (WHtR). In multivariable analysis, the subjects with high BMI (<i>p</i> < 0.001), WHR (<i>p</i> < 0.001), WHtR (<i>p</i> < 0.001), LAP (<i>p</i> = 0.002), BRI (<i>p</i> < 0.001), CI (<i>p</i> = 0.005), BAI (<i>p</i> < 0.001), and AVI (<i>p</i> < 0.001) were significantly associated with a high baseline FEV1/FVC. After 4 years of follow-up, the subjects with high BMI (<i>p</i> < 0.001), WHR (<i>p</i> < 0.001), WHtR (<i>p</i> < 0.001), LAP (<i>p</i> = 0.001), BRI (<i>p</i> < 0.001), CI (<i>p</i> = 0.002), BAI (<i>p</i> < 0.001), and AVI (<i>p</i> < 0.001) were significantly associated with a low △FEV1/FVC. High obesity-related index values were associated with better baseline lung function and a rapid decrease in lung function at follow-up. |
| first_indexed | 2024-03-10T05:10:38Z |
| format | Article |
| id | doaj.art-22cf51777e5a4c55b0af9b337787f80f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:10:38Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-22cf51777e5a4c55b0af9b337787f80f2023-11-23T00:49:55ZengMDPI AGNutrients2072-66432021-11-011311405510.3390/nu13114055Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up StudyYu-En Hsu0Szu-Chia Chen1Jiun-Hung Geng2Da-Wei Wu3Pei-Yu Wu4Jiun-Chi Huang5Department of Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanThe global pandemic of obesity and the increasing incidence of chronic respiratory diseases are growing health concerns. The association between obesity and pulmonary function is uncertain. Therefore, this study aimed to explore associations between changes in lung function and obesity-related indices in a large longitudinal study. A total of 9059 participants with no personal histories of asthma, smoking, bronchitis, or emphysema were enrolled from the Taiwan Biobank and followed for 4 years. Lung function was assessed using spirometry measurements including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). Changes in FEV1/FVC (∆FEV1/FVC) between baseline and follow-up were calculated. The following obesity-related indices were studied: lipid accumulation product (LAP), body roundness index (BRI), conicity index (CI), body adiposity index (BAI), abdominal volume index (AVI), body mass index (BMI), waist–hip ratio (WHR), and waist-to-height ratio (WHtR). In multivariable analysis, the subjects with high BMI (<i>p</i> < 0.001), WHR (<i>p</i> < 0.001), WHtR (<i>p</i> < 0.001), LAP (<i>p</i> = 0.002), BRI (<i>p</i> < 0.001), CI (<i>p</i> = 0.005), BAI (<i>p</i> < 0.001), and AVI (<i>p</i> < 0.001) were significantly associated with a high baseline FEV1/FVC. After 4 years of follow-up, the subjects with high BMI (<i>p</i> < 0.001), WHR (<i>p</i> < 0.001), WHtR (<i>p</i> < 0.001), LAP (<i>p</i> = 0.001), BRI (<i>p</i> < 0.001), CI (<i>p</i> = 0.002), BAI (<i>p</i> < 0.001), and AVI (<i>p</i> < 0.001) were significantly associated with a low △FEV1/FVC. High obesity-related index values were associated with better baseline lung function and a rapid decrease in lung function at follow-up.https://www.mdpi.com/2072-6643/13/11/4055obesity-related indexlung functionfollow-upTaiwan Biobank |
| spellingShingle | Yu-En Hsu Szu-Chia Chen Jiun-Hung Geng Da-Wei Wu Pei-Yu Wu Jiun-Chi Huang Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study Nutrients obesity-related index lung function follow-up Taiwan Biobank |
| title | Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study |
| title_full | Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study |
| title_fullStr | Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study |
| title_full_unstemmed | Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study |
| title_short | Obesity-Related Indices Are Associated with Longitudinal Changes in Lung Function: A Large Taiwanese Population Follow-Up Study |
| title_sort | obesity related indices are associated with longitudinal changes in lung function a large taiwanese population follow up study |
| topic | obesity-related index lung function follow-up Taiwan Biobank |
| url | https://www.mdpi.com/2072-6643/13/11/4055 |
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