eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

Background: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. Methods: Oxygen-induced retinopathy was used as a model...

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Bibliographic Details
Main Authors:	Takeshi Ninchoji, Dominic T Love, Ross O Smith, Marie Hedlund, Dietmar Vestweber, William C Sessa, Lena Claesson-Welsh
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-04-01
Series:	eLife
Subjects:	retinopathy of prematurity nitric oxide retinal vasculature vascular barrier VE-cadherin Src
Online Access:	https://elifesciences.org/articles/64944

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