CRISPR-based genome editing in primary human pancreatic islet cells
The editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22651-w |
| _version_ | 1818736740266934272 |
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| author | Romina J. Bevacqua Xiaoqing Dai Jonathan Y. Lam Xueying Gu Mollie S. H. Friedlander Krissie Tellez Irene Miguel-Escalada Silvia Bonàs-Guarch Goutham Atla Weichen Zhao Seung Hyun Kim Antonia A. Dominguez Lei S. Qi Jorge Ferrer Patrick E. MacDonald Seung K. Kim |
| author_facet | Romina J. Bevacqua Xiaoqing Dai Jonathan Y. Lam Xueying Gu Mollie S. H. Friedlander Krissie Tellez Irene Miguel-Escalada Silvia Bonàs-Guarch Goutham Atla Weichen Zhao Seung Hyun Kim Antonia A. Dominguez Lei S. Qi Jorge Ferrer Patrick E. MacDonald Seung K. Kim |
| author_sort | Romina J. Bevacqua |
| collection | DOAJ |
| description | The editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility. |
| first_indexed | 2024-12-18T00:41:57Z |
| format | Article |
| id | doaj.art-22d2b0339efc4aa29c30bb51db113c85 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:41:57Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-22d2b0339efc4aa29c30bb51db113c852022-12-21T21:26:52ZengNature PortfolioNature Communications2041-17232021-04-0112111210.1038/s41467-021-22651-wCRISPR-based genome editing in primary human pancreatic islet cellsRomina J. Bevacqua0Xiaoqing Dai1Jonathan Y. Lam2Xueying Gu3Mollie S. H. Friedlander4Krissie Tellez5Irene Miguel-Escalada6Silvia Bonàs-Guarch7Goutham Atla8Weichen Zhao9Seung Hyun Kim10Antonia A. Dominguez11Lei S. Qi12Jorge Ferrer13Patrick E. MacDonald14Seung K. Kim15Department of Developmental Biology, Stanford University School of MedicineAlberta Diabetes Institute and Department of Pharmacology, University of AlbertaDepartment of Developmental Biology, Stanford University School of MedicineDepartment of Developmental Biology, Stanford University School of MedicineDepartment of Developmental Biology, Stanford University School of MedicineDepartment of Developmental Biology, Stanford University School of MedicineBioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST)Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST)Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST)Department of Developmental Biology, Stanford University School of MedicineDepartment of Developmental Biology, Stanford University School of MedicineDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityBioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST)Alberta Diabetes Institute and Department of Pharmacology, University of AlbertaDepartment of Developmental Biology, Stanford University School of MedicineThe editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility.https://doi.org/10.1038/s41467-021-22651-w |
| spellingShingle | Romina J. Bevacqua Xiaoqing Dai Jonathan Y. Lam Xueying Gu Mollie S. H. Friedlander Krissie Tellez Irene Miguel-Escalada Silvia Bonàs-Guarch Goutham Atla Weichen Zhao Seung Hyun Kim Antonia A. Dominguez Lei S. Qi Jorge Ferrer Patrick E. MacDonald Seung K. Kim CRISPR-based genome editing in primary human pancreatic islet cells Nature Communications |
| title | CRISPR-based genome editing in primary human pancreatic islet cells |
| title_full | CRISPR-based genome editing in primary human pancreatic islet cells |
| title_fullStr | CRISPR-based genome editing in primary human pancreatic islet cells |
| title_full_unstemmed | CRISPR-based genome editing in primary human pancreatic islet cells |
| title_short | CRISPR-based genome editing in primary human pancreatic islet cells |
| title_sort | crispr based genome editing in primary human pancreatic islet cells |
| url | https://doi.org/10.1038/s41467-021-22651-w |
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