Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder worldwide. Murine models of NAFLD have been widely used to explore its pathogenesis. In this study, we performed a systematic evaluation of hepatic genome-wide mRNA expression by RNA-Sequencing using three mo...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2022-01-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304221000283 |
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| author | Liping Xiang Yang Jiao Yiling Qian Yao Li Fei Mao Yan Lu |
| author_facet | Liping Xiang Yang Jiao Yiling Qian Yao Li Fei Mao Yan Lu |
| author_sort | Liping Xiang |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder worldwide. Murine models of NAFLD have been widely used to explore its pathogenesis. In this study, we performed a systematic evaluation of hepatic genome-wide mRNA expression by RNA-Sequencing using three mouse models of NAFLD: leptin receptor deficient db/db mice, high-fat high-sugar diet (HSHF)-induced obese mice, and dexamethasone (DEX)-induced NAFLD mice. As a result, we found both distinct and common pathways in the regulation of lipid metabolism from transcriptomes of three mouse models. Moreover, only a total of 12 differentially expressed genes (DEGs) were commonly detected among all three mouse groups, indicating very little overlap among all three models. Therefore, our results suggest that NAFLD is a heterogeneous disease with highly variable molecular mechanisms. |
| first_indexed | 2024-03-12T20:27:03Z |
| format | Article |
| id | doaj.art-22d3292f541f4d3280d400d8b3f04300 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T20:27:03Z |
| publishDate | 2022-01-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Genes and Diseases |
| spelling | doaj.art-22d3292f541f4d3280d400d8b3f043002023-08-02T00:26:09ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422022-01-0191201215Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver DiseaseLiping Xiang0Yang Jiao1Yiling Qian2Yao Li3Fei Mao4Yan Lu5Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, PR ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, PR ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China; Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai 200032, PR ChinaDepartment of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China; Corresponding author.Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China; Corresponding author.Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder worldwide. Murine models of NAFLD have been widely used to explore its pathogenesis. In this study, we performed a systematic evaluation of hepatic genome-wide mRNA expression by RNA-Sequencing using three mouse models of NAFLD: leptin receptor deficient db/db mice, high-fat high-sugar diet (HSHF)-induced obese mice, and dexamethasone (DEX)-induced NAFLD mice. As a result, we found both distinct and common pathways in the regulation of lipid metabolism from transcriptomes of three mouse models. Moreover, only a total of 12 differentially expressed genes (DEGs) were commonly detected among all three mouse groups, indicating very little overlap among all three models. Therefore, our results suggest that NAFLD is a heterogeneous disease with highly variable molecular mechanisms.http://www.sciencedirect.com/science/article/pii/S2352304221000283DEGsMurine modelsNAFLDPathway analysisTranscriptome |
| spellingShingle | Liping Xiang Yang Jiao Yiling Qian Yao Li Fei Mao Yan Lu Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease Genes and Diseases DEGs Murine models NAFLD Pathway analysis Transcriptome |
| title | Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease |
| title_full | Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease |
| title_fullStr | Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease |
| title_short | Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease |
| title_sort | comparison of hepatic gene expression profiles between three mouse models of nonalcoholic fatty liver disease |
| topic | DEGs Murine models NAFLD Pathway analysis Transcriptome |
| url | http://www.sciencedirect.com/science/article/pii/S2352304221000283 |
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