Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-09-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124714006688 |
| _version_ | 1819058317896450048 |
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| author | Cristina Villa del Campo Cristina Clavería Rocío Sierra Miguel Torres |
| author_facet | Cristina Villa del Campo Cristina Clavería Rocío Sierra Miguel Torres |
| author_sort | Cristina Villa del Campo |
| collection | DOAJ |
| description | Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardiomyocyte-replacement strategy. |
| first_indexed | 2024-12-21T13:53:17Z |
| format | Article |
| id | doaj.art-22d64f56d99148d2bf5cf464cf578b0c |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T13:53:17Z |
| publishDate | 2014-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-22d64f56d99148d2bf5cf464cf578b0c2022-12-21T19:01:37ZengElsevierCell Reports2211-12472014-09-01861741175110.1016/j.celrep.2014.08.005Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian HeartCristina Villa del Campo0Cristina Clavería1Rocío Sierra2Miguel Torres3Departamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/ Melchor Fernández Almagro, 3, E-28029 Madrid, SpainDepartamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/ Melchor Fernández Almagro, 3, E-28029 Madrid, SpainDepartamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/ Melchor Fernández Almagro, 3, E-28029 Madrid, SpainDepartamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/ Melchor Fernández Almagro, 3, E-28029 Madrid, SpainHeterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardiomyocyte-replacement strategy.http://www.sciencedirect.com/science/article/pii/S2211124714006688 |
| spellingShingle | Cristina Villa del Campo Cristina Clavería Rocío Sierra Miguel Torres Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart Cell Reports |
| title | Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart |
| title_full | Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart |
| title_fullStr | Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart |
| title_full_unstemmed | Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart |
| title_short | Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart |
| title_sort | cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart |
| url | http://www.sciencedirect.com/science/article/pii/S2211124714006688 |
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