Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models
Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this review, we summarize how multiphoto...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2020.592607/full |
| _version_ | 1819061075584221184 |
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| author | Jaichandar Subramanian Julie C. Savage Marie-Ève Tremblay Marie-Ève Tremblay Marie-Ève Tremblay Marie-Ève Tremblay |
| author_facet | Jaichandar Subramanian Julie C. Savage Marie-Ève Tremblay Marie-Ève Tremblay Marie-Ève Tremblay Marie-Ève Tremblay |
| author_sort | Jaichandar Subramanian |
| collection | DOAJ |
| description | Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this review, we summarize how multiphoton in vivo imaging has improved our understanding of synapse loss mechanisms associated with excessive amyloid in the living animal brain. We also discuss evidence obtained from these imaging studies for the role of cell-intrinsic calcium dyshomeostasis and cell-extrinsic activities of microglia, which are the immune cells of the brain, in mediating synapse loss. |
| first_indexed | 2024-12-21T14:37:07Z |
| format | Article |
| id | doaj.art-22d69a7f53b244da813c034e3632b99b |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-21T14:37:07Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-22d69a7f53b244da813c034e3632b99b2022-12-21T19:00:17ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-12-011410.3389/fncel.2020.592607592607Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse ModelsJaichandar Subramanian0Julie C. Savage1Marie-Ève Tremblay2Marie-Ève Tremblay3Marie-Ève Tremblay4Marie-Ève Tremblay5Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United StatesAxe Neurosciences, Centre de Recherche du CHU de Québec, Université Laval, Québec City, QC, CanadaNeurology and Neurosurgery Department, McGill University, Montreal, QC, CanadaDepartment of Molecular Medicine, Université Laval, Québec City, QC, CanadaDivision of Medical Sciences, University of Victoria, Victoria, BC, CanadaDepartment of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, CanadaSynapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this review, we summarize how multiphoton in vivo imaging has improved our understanding of synapse loss mechanisms associated with excessive amyloid in the living animal brain. We also discuss evidence obtained from these imaging studies for the role of cell-intrinsic calcium dyshomeostasis and cell-extrinsic activities of microglia, which are the immune cells of the brain, in mediating synapse loss.https://www.frontiersin.org/articles/10.3389/fncel.2020.592607/fulldendritic spinesmicrogliatwo-photonin vivo imagingamyloid mouse models |
| spellingShingle | Jaichandar Subramanian Julie C. Savage Marie-Ève Tremblay Marie-Ève Tremblay Marie-Ève Tremblay Marie-Ève Tremblay Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models Frontiers in Cellular Neuroscience dendritic spines microglia two-photon in vivo imaging amyloid mouse models |
| title | Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models |
| title_full | Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models |
| title_fullStr | Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models |
| title_full_unstemmed | Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models |
| title_short | Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models |
| title_sort | synaptic loss in alzheimer s disease mechanistic insights provided by two photon in vivo imaging of transgenic mouse models |
| topic | dendritic spines microglia two-photon in vivo imaging amyloid mouse models |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2020.592607/full |
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