Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
ABSTRACT The opportunistic pathogen Toxoplasma gondii is highly adept at manipulating host cell functions. While inside a host cell, Toxoplasma divides within a parasitophorous vacuole from which it secretes numerous effector proteins from its dense granules. Many of these so-called GRA proteins are...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2019-08-01
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| Series: | mSphere |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00523-19 |
| _version_ | 1818856746704175104 |
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| author | Gustavo Arrizabalaga |
| author_facet | Gustavo Arrizabalaga |
| author_sort | Gustavo Arrizabalaga |
| collection | DOAJ |
| description | ABSTRACT The opportunistic pathogen Toxoplasma gondii is highly adept at manipulating host cell functions. While inside a host cell, Toxoplasma divides within a parasitophorous vacuole from which it secretes numerous effector proteins from its dense granules. Many of these so-called GRA proteins are translocated from the parsitophorous vacuole into the host cell where they directly disrupt host signaling pathways. The machinery that drives the translocation of GRA proteins across the parasitophorous vacuole membrane is being elucidated through both genetic and biochemical approaches. A new mSphere research article (M. W. Panas, A. Ferrel, A. Naor, E. Tenborg, et al., mSphere 4:e00276-19, 2019, https://doi.org/10.1128/mSphere.00276-19) describes how the kinase ROP17, which is secreted from the parasite’s rhoptries into the host cell during invasion, regulates the translocation of GRA effectors. |
| first_indexed | 2024-12-19T08:29:24Z |
| format | Article |
| id | doaj.art-22d992b21b9740819ea0b6533d97f199 |
| institution | Directory Open Access Journal |
| issn | 2379-5042 |
| language | English |
| last_indexed | 2024-12-19T08:29:24Z |
| publishDate | 2019-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSphere |
| spelling | doaj.art-22d992b21b9740819ea0b6533d97f1992022-12-21T20:29:13ZengAmerican Society for MicrobiologymSphere2379-50422019-08-014410.1128/mSphere.00523-19Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host CellGustavo Arrizabalaga0Indiana University School of Medicine, Indianapolis, Indiana, USAABSTRACT The opportunistic pathogen Toxoplasma gondii is highly adept at manipulating host cell functions. While inside a host cell, Toxoplasma divides within a parasitophorous vacuole from which it secretes numerous effector proteins from its dense granules. Many of these so-called GRA proteins are translocated from the parsitophorous vacuole into the host cell where they directly disrupt host signaling pathways. The machinery that drives the translocation of GRA proteins across the parasitophorous vacuole membrane is being elucidated through both genetic and biochemical approaches. A new mSphere research article (M. W. Panas, A. Ferrel, A. Naor, E. Tenborg, et al., mSphere 4:e00276-19, 2019, https://doi.org/10.1128/mSphere.00276-19) describes how the kinase ROP17, which is secreted from the parasite’s rhoptries into the host cell during invasion, regulates the translocation of GRA effectors.https://journals.asm.org/doi/10.1128/mSphere.00523-19GRA16GRA24MYR1ROP17Toxoplasma gondiic-MYC |
| spellingShingle | Gustavo Arrizabalaga Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell mSphere GRA16 GRA24 MYR1 ROP17 Toxoplasma gondii c-MYC |
| title | Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell |
| title_full | Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell |
| title_fullStr | Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell |
| title_full_unstemmed | Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell |
| title_short | Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell |
| title_sort | neighbors working together a italic toggle yes toxoplasma italic rhoptry protein that facilitates dense granule protein translocation into the host cell |
| topic | GRA16 GRA24 MYR1 ROP17 Toxoplasma gondii c-MYC |
| url | https://journals.asm.org/doi/10.1128/mSphere.00523-19 |
| work_keys_str_mv | AT gustavoarrizabalaga neighborsworkingtogetheraitalictoggleyestoxoplasmaitalicrhoptryproteinthatfacilitatesdensegranuleproteintranslocationintothehostcell |