SIRT1 in the Brain – Connections with Aging-associated Disorders and Lifespan
The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-03-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00064/full |
| _version_ | 1818131694680539136 |
|---|---|
| author | Fanny eNg Laura eWijaya Bor Luen eTang Bor Luen eTang |
| author_facet | Fanny eNg Laura eWijaya Bor Luen eTang Bor Luen eTang |
| author_sort | Fanny eNg |
| collection | DOAJ |
| description | The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of SIRT1’s role that impinges on aging and lifespan may lie in its activities in the central nervous system (CNS) neurons. Systemically, SIRT1 influences energy metabolism and circadian rhythm through its activity in the hypothalamic nuclei. From a cell biological perspective, SIRT1 is a crucial component of multiple interconnected regulatory networks that modulate dendritic and axonal growth, as well as survival against stress. This neuronal cell autonomous activity of SIRT1 is also important for neuronal plasticity, cognitive functions, as well as protection against aging-associated neuronal degeneration and cognitive decline. We discuss recent findings that have shed light on the various activities of SIRT1 in the brain, which collectively impinge on aging-associated disorders and lifespan. |
| first_indexed | 2024-12-11T08:25:01Z |
| format | Article |
| id | doaj.art-22d9f0c456fa4285851706cfd907b3ca |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T08:25:01Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-22d9f0c456fa4285851706cfd907b3ca2022-12-22T01:14:34ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-03-01910.3389/fncel.2015.00064134618SIRT1 in the Brain – Connections with Aging-associated Disorders and LifespanFanny eNg0Laura eWijaya1Bor Luen eTang2Bor Luen eTang3National University of SingaporeNational University of SingaporeNational University of SingaporeNUS Graduate School for Integrative Sciences and EngineeringThe silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of SIRT1’s role that impinges on aging and lifespan may lie in its activities in the central nervous system (CNS) neurons. Systemically, SIRT1 influences energy metabolism and circadian rhythm through its activity in the hypothalamic nuclei. From a cell biological perspective, SIRT1 is a crucial component of multiple interconnected regulatory networks that modulate dendritic and axonal growth, as well as survival against stress. This neuronal cell autonomous activity of SIRT1 is also important for neuronal plasticity, cognitive functions, as well as protection against aging-associated neuronal degeneration and cognitive decline. We discuss recent findings that have shed light on the various activities of SIRT1 in the brain, which collectively impinge on aging-associated disorders and lifespan.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00064/fullAgingCognitionMetabolismneurodegenerationSIRT1 |
| spellingShingle | Fanny eNg Laura eWijaya Bor Luen eTang Bor Luen eTang SIRT1 in the Brain – Connections with Aging-associated Disorders and Lifespan Frontiers in Cellular Neuroscience Aging Cognition Metabolism neurodegeneration SIRT1 |
| title | SIRT1 in the Brain – Connections with Aging-associated Disorders and Lifespan |
| title_full | SIRT1 in the Brain – Connections with Aging-associated Disorders and Lifespan |
| title_fullStr | SIRT1 in the Brain – Connections with Aging-associated Disorders and Lifespan |
| title_full_unstemmed | SIRT1 in the Brain – Connections with Aging-associated Disorders and Lifespan |
| title_short | SIRT1 in the Brain – Connections with Aging-associated Disorders and Lifespan |
| title_sort | sirt1 in the brain connections with aging associated disorders and lifespan |
| topic | Aging Cognition Metabolism neurodegeneration SIRT1 |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00064/full |
| work_keys_str_mv | AT fannyeng sirt1inthebrainconnectionswithagingassociateddisordersandlifespan AT lauraewijaya sirt1inthebrainconnectionswithagingassociateddisordersandlifespan AT borluenetang sirt1inthebrainconnectionswithagingassociateddisordersandlifespan AT borluenetang sirt1inthebrainconnectionswithagingassociateddisordersandlifespan |