Systematic Genetic Interaction Analysis Identifies a Transcription Factor Circuit Required for Oropharyngeal Candidiasis

Systematic Genetic Interaction Analysis Identifies a Transcription Factor Circuit Required for Oropharyngeal Candidiasis

ABSTRACT Oropharyngeal candidiasis (OPC) is a common infection that complicates a wide range of medical conditions and can cause either mild or severe disease depending on the patient. The pathobiology of OPC shares many features with candidal biofilms of abiotic surfaces. The transcriptional regula...

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Bibliographic Details
Main Authors: Norma V. Solis, Rohan S. Wakade, Virginia E. Glazier, Tomye L. Ollinger, Melanie Wellington, Aaron P. Mitchell, Scott G. Filler, Damian J. Krysan
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
Candida albicans
biofilms
complex haploinsufficiency
oropharyngeal candidiasis
Online Access:https://journals.asm.org/doi/10.1128/mbio.03447-21

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