Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions
Epigenetic mechanisms play a primary role in the cellular damage associated with brain aging. Histone posttranslational modifications represent intrinsic molecular alterations essential for proper physiological functioning, while divergent expression and activity have been detected in several aspect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/24/17339 |
| _version_ | 1797380748469075968 |
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| author | Nikolaos Vitorakis Christina Piperi |
| author_facet | Nikolaos Vitorakis Christina Piperi |
| author_sort | Nikolaos Vitorakis |
| collection | DOAJ |
| description | Epigenetic mechanisms play a primary role in the cellular damage associated with brain aging. Histone posttranslational modifications represent intrinsic molecular alterations essential for proper physiological functioning, while divergent expression and activity have been detected in several aspects of brain aging. Aberrant histone methylation has been involved in neural stem cell (NSC) quiescence, microglial deficits, inflammatory processes, memory impairment, cognitive decline, neurodegenerative diseases, and schizophrenia. Herein, we provide an overview of recent studies on epigenetic regulation of brain tissue aging, mainly focusing on the role of histone methylation in different cellular and functional aspects of the aging process. Emerging targeting strategies of histone methylation are further explored, including neuroprotective drugs, natural compounds, and lifestyle modifications with therapeutic potential towards the aging process of the brain. |
| first_indexed | 2024-03-08T20:41:33Z |
| format | Article |
| id | doaj.art-22de20a3615444858a66237956fbb412 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T20:41:33Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-22de20a3615444858a66237956fbb4122023-12-22T14:14:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241733910.3390/ijms242417339Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic InterventionsNikolaos Vitorakis0Christina Piperi1Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 M. Asias Street, 11527 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 M. Asias Street, 11527 Athens, GreeceEpigenetic mechanisms play a primary role in the cellular damage associated with brain aging. Histone posttranslational modifications represent intrinsic molecular alterations essential for proper physiological functioning, while divergent expression and activity have been detected in several aspects of brain aging. Aberrant histone methylation has been involved in neural stem cell (NSC) quiescence, microglial deficits, inflammatory processes, memory impairment, cognitive decline, neurodegenerative diseases, and schizophrenia. Herein, we provide an overview of recent studies on epigenetic regulation of brain tissue aging, mainly focusing on the role of histone methylation in different cellular and functional aspects of the aging process. Emerging targeting strategies of histone methylation are further explored, including neuroprotective drugs, natural compounds, and lifestyle modifications with therapeutic potential towards the aging process of the brain.https://www.mdpi.com/1422-0067/24/24/17339histonesmethylationagingbrainhistone marksH3K4me3 |
| spellingShingle | Nikolaos Vitorakis Christina Piperi Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions International Journal of Molecular Sciences histones methylation aging brain histone marks H3K4me3 |
| title | Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions |
| title_full | Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions |
| title_fullStr | Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions |
| title_full_unstemmed | Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions |
| title_short | Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions |
| title_sort | insights into the role of histone methylation in brain aging and potential therapeutic interventions |
| topic | histones methylation aging brain histone marks H3K4me3 |
| url | https://www.mdpi.com/1422-0067/24/24/17339 |
| work_keys_str_mv | AT nikolaosvitorakis insightsintotheroleofhistonemethylationinbrainagingandpotentialtherapeuticinterventions AT christinapiperi insightsintotheroleofhistonemethylationinbrainagingandpotentialtherapeuticinterventions |