Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions

Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions

Epigenetic mechanisms play a primary role in the cellular damage associated with brain aging. Histone posttranslational modifications represent intrinsic molecular alterations essential for proper physiological functioning, while divergent expression and activity have been detected in several aspect...

Full description

Bibliographic Details
Main Authors:	Nikolaos Vitorakis, Christina Piperi
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	International Journal of Molecular Sciences
Subjects:	histones methylation aging brain histone marks H3K4me3
Online Access:	https://www.mdpi.com/1422-0067/24/24/17339

Similar Items

Epigenetic Consequences of in Utero Exposure to Rosuvastatin: Alteration of Histone Methylation Patterns in Newborn Rat Brains
by: Karolina Dulka, et al.
Published: (2021-03-01)

In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse
by: Marco Morselli, et al.
Published: (2015-04-01)

Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease
by: Alejandra Agredo, et al.
Published: (2023-08-01)

Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation
by: Bradley P. Balaton, et al.
Published: (2021-06-01)

DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism
by: Ali Sharifi-Zarchi, et al.
Published: (2017-12-01)

Changes in histone H3 lysine 4 trimethylation in Hashimoto’s thyroiditis
by: Xixuan Lu, et al.
Published: (2019-05-01)

Histone H3 lysine K4 methylation and its role in learning and memory
by: Bridget E. Collins, et al.
Published: (2019-01-01)

Changes Within H3K4me3-Marked Histone Reveal Molecular Background of Neutrophil Functional Plasticity
by: Paweł Piatek, et al.
Published: (2022-06-01)

Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome
by: Kyle K. Biggar, et al.
Published: (2020-07-01)

Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription
by: Zhen Zhou, et al.
Published: (2017-10-01)

Characterization of Histone H3 Lysine 4 and 36 Tri-methylation in Brassica rapa L.
by: Hasan Mehraj, et al.
Published: (2021-06-01)

Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line
by: Xiao-fei WANG, et al.
Published: (2020-02-01)

Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain
by: Pritika J. Narayan, et al.
Published: (2015-02-01)

Epigenetic regulation of gene responsiveness in Arabidopsis
by: Taiko Kim To, et al.
Published: (2014-01-01)

Identification of novel genes associated with HIV-1 latency by analysis of histone modifications
by: Kyung-Chang Kim, et al.
Published: (2017-05-01)

Notch and Wnt Signaling Modulation to Enhance DPSC Stemness and Therapeutic Potential
by: Verónica Uribe-Etxebarria, et al.
Published: (2023-04-01)

Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains
by: Melinda Szabo, et al.
Published: (2022-01-01)

Expression and clinical significance of H3K27me3 in hemangioma and vascular malformation
by: WANG Junlan, et al.
Published: (2022-07-01)

A Hypomethylating Ketogenic Diet in Apolipoprotein E-Deficient Mice: A Pilot Study on Vascular Effects and Specific Epigenetic Changes
by: Rita Castro, et al.
Published: (2021-10-01)

Digital imaging-assisted quantification of H3K27me3 immunoexpression in luminal A/B-like, HER2-negative, invasive breast cancer predicts patient survival and risk of recurrence
by: Mário Fontes-Sousa, et al.
Published: (2020-02-01)

Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer
by: Miaomiao Yu, et al.
Published: (2022-08-01)

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
by: David A. Brown, et al.
Published: (2017-09-01)

Control of Intra-Thymic αβ T Cell Selection and Maturation by H3K27 Methylation and Demethylation
by: Rémy Bosselut
Published: (2019-04-01)

Differential enrichment of H3K9me3 at annotated satellite DNA repeats in human cell lines and during fetal development in mouse
by: Tanja Vojvoda Zeljko, et al.
Published: (2021-10-01)

Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome
by: Li Zhang, et al.
Published: (2021-03-01)

The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana
by: Heike Wollmann, et al.
Published: (2017-05-01)

The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif
by: Xingyin Liu, et al.
Published: (2015-12-01)

Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression
by: Panxia Wang, et al.
Published: (2020-09-01)

H4K20me3 upregulated by reactive oxygen species is associated with tumor progression and poor prognosis in patients with hepatocellular carcinoma
by: Suchittra Phoyen, et al.
Published: (2023-12-01)

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers
by: Brianna J. Klein, et al.
Published: (2018-07-01)

A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
by: Chun-Min Shan, et al.
Published: (2016-09-01)

Genome-wide profiling of histone H3 lysine 27 trimethylation and its modification in response to chilling stress in grapevine leaves
by: Zhenfei Zhu, et al.
Published: (2023-06-01)

Histone Demethylases JMJ30 and JMJ32 Modulate the Speed of Vernalization Through the Activation of FLOWERING LOCUS C in Arabidopsis thaliana
by: Takashi Maruoka, et al.
Published: (2022-07-01)

GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling
by: Laia Sadeghi, et al.
Published: (2023-08-01)

De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
by: David A. Vinson, et al.
Published: (2022-11-01)

The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice
by: Seul Lee, et al.
Published: (2020-05-01)

Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells
by: Sue Yu, et al.
Published: (2022-02-01)

Impact of Histone Modifications and Their Therapeutic Targeting in Hematological Malignancies
by: Mariam Markouli, et al.
Published: (2022-11-01)

Recent insights into Histone Acetyltransferase-1: biological function and involvement in pathogenesis
by: Angelita Poziello, et al.
Published: (2021-08-01)

Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring
by: Wei Chen, et al.
Published: (2020-11-01)