Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease
Sleep-disordered breathing is a risk factor for Alzheimer’s disease. Here the authors use mesopontine tegmentum lesion to model sleep disordered breathing in a mouse model of Alzheimer’s disease, and find that some features of the Alzheimer’s disease-like phenotype are exacerbated.
Bibliographic Details
| Main Authors: |
Lei Qian,
Oliver Rawashdeh,
Leda Kasas,
Michael R. Milne,
Nicholas Garner,
Kornraviya Sankorrakul,
Nicola Marks,
Matthew W. Dean,
Pu Reum Kim,
Aanchal Sharma,
Mark C. Bellingham,
Elizabeth J. Coulson |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-33624-y
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