Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease
Sleep-disordered breathing is a risk factor for Alzheimer’s disease. Here the authors use mesopontine tegmentum lesion to model sleep disordered breathing in a mouse model of Alzheimer’s disease, and find that some features of the Alzheimer’s disease-like phenotype are exacerbated.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33624-y |
| _version_ | 1798044291033989120 |
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| author | Lei Qian Oliver Rawashdeh Leda Kasas Michael R. Milne Nicholas Garner Kornraviya Sankorrakul Nicola Marks Matthew W. Dean Pu Reum Kim Aanchal Sharma Mark C. Bellingham Elizabeth J. Coulson |
| author_facet | Lei Qian Oliver Rawashdeh Leda Kasas Michael R. Milne Nicholas Garner Kornraviya Sankorrakul Nicola Marks Matthew W. Dean Pu Reum Kim Aanchal Sharma Mark C. Bellingham Elizabeth J. Coulson |
| author_sort | Lei Qian |
| collection | DOAJ |
| description | Sleep-disordered breathing is a risk factor for Alzheimer’s disease. Here the authors use mesopontine tegmentum lesion to model sleep disordered breathing in a mouse model of Alzheimer’s disease, and find that some features of the Alzheimer’s disease-like phenotype are exacerbated. |
| first_indexed | 2024-04-11T23:01:25Z |
| format | Article |
| id | doaj.art-22de7d61738d47849857fbf106da033e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T23:01:25Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-22de7d61738d47849857fbf106da033e2022-12-22T03:58:07ZengNature PortfolioNature Communications2041-17232022-11-0113111810.1038/s41467-022-33624-yCholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s diseaseLei Qian0Oliver Rawashdeh1Leda Kasas2Michael R. Milne3Nicholas Garner4Kornraviya Sankorrakul5Nicola Marks6Matthew W. Dean7Pu Reum Kim8Aanchal Sharma9Mark C. Bellingham10Elizabeth J. Coulson11Queensland Brain Institute, The University of QueenslandSchool of Biomedical Sciences, Faculty of Medicine, The University of QueenslandSchool of Biomedical Sciences, Faculty of Medicine, The University of QueenslandQueensland Brain Institute, The University of QueenslandSchool of Biomedical Sciences, Faculty of Medicine, The University of QueenslandSchool of Biomedical Sciences, Faculty of Medicine, The University of QueenslandQueensland Brain Institute, The University of QueenslandSchool of Biomedical Sciences, Faculty of Medicine, The University of QueenslandSchool of Biomedical Sciences, Faculty of Medicine, The University of QueenslandQueensland Brain Institute, The University of QueenslandSchool of Biomedical Sciences, Faculty of Medicine, The University of QueenslandQueensland Brain Institute, The University of QueenslandSleep-disordered breathing is a risk factor for Alzheimer’s disease. Here the authors use mesopontine tegmentum lesion to model sleep disordered breathing in a mouse model of Alzheimer’s disease, and find that some features of the Alzheimer’s disease-like phenotype are exacerbated.https://doi.org/10.1038/s41467-022-33624-y |
| spellingShingle | Lei Qian Oliver Rawashdeh Leda Kasas Michael R. Milne Nicholas Garner Kornraviya Sankorrakul Nicola Marks Matthew W. Dean Pu Reum Kim Aanchal Sharma Mark C. Bellingham Elizabeth J. Coulson Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease Nature Communications |
| title | Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease |
| title_full | Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease |
| title_fullStr | Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease |
| title_full_unstemmed | Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease |
| title_short | Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease |
| title_sort | cholinergic basal forebrain degeneration due to sleep disordered breathing exacerbates pathology in a mouse model of alzheimer s disease |
| url | https://doi.org/10.1038/s41467-022-33624-y |
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