Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females
Abstract Objective Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. This study was conducte...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-021-05608-6 |
| _version_ | 1818647003153825792 |
|---|---|
| author | Leila Setayesh Krista Casazza Nariman Moradi Sanaz Mehranfar Habib Yarizadeh Abbas Amini Mir Saeed Yekaninejad Khadijeh Mirzaei |
| author_facet | Leila Setayesh Krista Casazza Nariman Moradi Sanaz Mehranfar Habib Yarizadeh Abbas Amini Mir Saeed Yekaninejad Khadijeh Mirzaei |
| author_sort | Leila Setayesh |
| collection | DOAJ |
| description | Abstract Objective Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. This study was conducted to evaluate the relationships among 25(OH)D, VDBP, glucose/insulin metabolism and homeostatic model assessment (HOMA-IR). Blood samples were collected from 236 obese and overweight women. VDBP and 25(OH)D levels, and biochemical parameters were measured using an enzyme-linked immunosorbent assay (ELISA). An impedance fat analyzer was utilized to acquire the body composition. Results Using the multivariate linear regression, a reverse relationship was observed between VDBP and (HOMA-IR), such that women with higher VDBP displayed lower insulin resistance. The relationship was independent of age, body mass index, standardized energy intake and physical activity (p = 0.00). No significant relationship between 25(OH)D levels, FBS, body composition or insulin resistance were observed (p > 0.2). Current study observed that higher level of VDBP may be associated with lower levels of insulin and HOMA-IR, thus the evaluation of VDBP in diverse population groups seems to have significant clinical value in evaluating the prevalence of DM or early stage of glucose intolerance. |
| first_indexed | 2024-12-17T00:55:37Z |
| format | Article |
| id | doaj.art-22e2bab07c9447a0ae3a4f34e5cbbb36 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-17T00:55:37Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-22e2bab07c9447a0ae3a4f34e5cbbb362022-12-21T22:09:37ZengBMCBMC Research Notes1756-05002021-05-011411710.1186/s13104-021-05608-6Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese femalesLeila Setayesh0Krista Casazza1Nariman Moradi2Sanaz Mehranfar3Habib Yarizadeh4Abbas Amini5Mir Saeed Yekaninejad6Khadijeh Mirzaei7Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesMarieb College of Health and Human Services, Florida Gulf Coast UniversityCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Mechanical Engineering, Australian College of KuwaitDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesAbstract Objective Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. This study was conducted to evaluate the relationships among 25(OH)D, VDBP, glucose/insulin metabolism and homeostatic model assessment (HOMA-IR). Blood samples were collected from 236 obese and overweight women. VDBP and 25(OH)D levels, and biochemical parameters were measured using an enzyme-linked immunosorbent assay (ELISA). An impedance fat analyzer was utilized to acquire the body composition. Results Using the multivariate linear regression, a reverse relationship was observed between VDBP and (HOMA-IR), such that women with higher VDBP displayed lower insulin resistance. The relationship was independent of age, body mass index, standardized energy intake and physical activity (p = 0.00). No significant relationship between 25(OH)D levels, FBS, body composition or insulin resistance were observed (p > 0.2). Current study observed that higher level of VDBP may be associated with lower levels of insulin and HOMA-IR, thus the evaluation of VDBP in diverse population groups seems to have significant clinical value in evaluating the prevalence of DM or early stage of glucose intolerance.https://doi.org/10.1186/s13104-021-05608-6Vitamin D binding proteinVitamin D3ObesityDiabetes mellitusInsulinHomeostatic model assessment (HOMA-IR) |
| spellingShingle | Leila Setayesh Krista Casazza Nariman Moradi Sanaz Mehranfar Habib Yarizadeh Abbas Amini Mir Saeed Yekaninejad Khadijeh Mirzaei Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females BMC Research Notes Vitamin D binding protein Vitamin D3 Obesity Diabetes mellitus Insulin Homeostatic model assessment (HOMA-IR) |
| title | Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females |
| title_full | Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females |
| title_fullStr | Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females |
| title_full_unstemmed | Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females |
| title_short | Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females |
| title_sort | association of vitamin d binding protein and vitamin d3 with insulin and homeostatic model assessment homa ir in overweight and obese females |
| topic | Vitamin D binding protein Vitamin D3 Obesity Diabetes mellitus Insulin Homeostatic model assessment (HOMA-IR) |
| url | https://doi.org/10.1186/s13104-021-05608-6 |
| work_keys_str_mv | AT leilasetayesh associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales AT kristacasazza associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales AT narimanmoradi associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales AT sanazmehranfar associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales AT habibyarizadeh associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales AT abbasamini associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales AT mirsaeedyekaninejad associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales AT khadijehmirzaei associationofvitamindbindingproteinandvitamind3withinsulinandhomeostaticmodelassessmenthomairinoverweightandobesefemales |