Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid)
AbstractBee propolis has been used in alternative medicine to treat various diseases. Due to its limited water solubility, it is often used in combination with alcohol solvents, causing skin irritation and immune response. To solve this, the new drug delivery system, based on the lipid nanodiscs of...
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| Format: | Article |
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Taylor & Francis Group
2023-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2023.2198570 |
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| author | Chatmani Buachi Charothar Thammachai Brian J. Tighe Paul D. Topham Robert Molloy Patchara Punyamoonwongsa |
| author_facet | Chatmani Buachi Charothar Thammachai Brian J. Tighe Paul D. Topham Robert Molloy Patchara Punyamoonwongsa |
| author_sort | Chatmani Buachi |
| collection | DOAJ |
| description | AbstractBee propolis has been used in alternative medicine to treat various diseases. Due to its limited water solubility, it is often used in combination with alcohol solvents, causing skin irritation and immune response. To solve this, the new drug delivery system, based on the lipid nanodiscs of 1,2-dimyristoyl-sn-glycero-3-phosphochline (DMPC) and poly(styrene-alt-maleic acid) (PSMA), were created in an aqueous media. At the excess polymer concentrations, the PSMA/DMPC complexation produced the very fine nanoparticles (18 nm). With the increased molar ratio of styrene to maleic acid (St/MA) in the copolymer structure, the lipid nanodisc showed the improved encapsulation efficiency (EE%), comparing to their corresponding aqueous formulations. The maximum value had reached to around 20% when using the 2:1 PSMA precursor. Based on the cytotoxicity test, these nanoparticles were considered to be non-toxic over the low dose administration region (<78 µg/mL). Instead, they possessed the ability to promote the Vero cell growth. The new PSMA/DMPC nanovesicles could thus be used to improve aqueous solubility and therapeutic effects of poorly water-soluble drugs, thus extending their use in modern therapies. |
| first_indexed | 2024-03-11T11:18:11Z |
| format | Article |
| id | doaj.art-22e37a52946c4d2da1fa807a7de5bf33 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-11T11:18:11Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-22e37a52946c4d2da1fa807a7de5bf332023-11-10T17:19:32ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2023-12-0151119220410.1080/21691401.2023.2198570Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid)Chatmani Buachi0Charothar Thammachai1Brian J. Tighe2Paul D. Topham3Robert Molloy4Patchara Punyamoonwongsa5School of Science, Mae Fah Luang University, Chiangrai, ThailandSchool of Science, Mae Fah Luang University, Chiangrai, ThailandAston Institute of Material Research, Aston University, Birmingham, UKAston Institute of Material Research, Aston University, Birmingham, UKPolymer Research Group, Department of Chemistry, Materials Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai, ThailandSchool of Science, Mae Fah Luang University, Chiangrai, ThailandAbstractBee propolis has been used in alternative medicine to treat various diseases. Due to its limited water solubility, it is often used in combination with alcohol solvents, causing skin irritation and immune response. To solve this, the new drug delivery system, based on the lipid nanodiscs of 1,2-dimyristoyl-sn-glycero-3-phosphochline (DMPC) and poly(styrene-alt-maleic acid) (PSMA), were created in an aqueous media. At the excess polymer concentrations, the PSMA/DMPC complexation produced the very fine nanoparticles (18 nm). With the increased molar ratio of styrene to maleic acid (St/MA) in the copolymer structure, the lipid nanodisc showed the improved encapsulation efficiency (EE%), comparing to their corresponding aqueous formulations. The maximum value had reached to around 20% when using the 2:1 PSMA precursor. Based on the cytotoxicity test, these nanoparticles were considered to be non-toxic over the low dose administration region (<78 µg/mL). Instead, they possessed the ability to promote the Vero cell growth. The new PSMA/DMPC nanovesicles could thus be used to improve aqueous solubility and therapeutic effects of poorly water-soluble drugs, thus extending their use in modern therapies.https://www.tandfonline.com/doi/10.1080/21691401.2023.2198570Nanodiscsbiomimeticdrug deliverypropolisstyrene maleic acidnanoencapsulation |
| spellingShingle | Chatmani Buachi Charothar Thammachai Brian J. Tighe Paul D. Topham Robert Molloy Patchara Punyamoonwongsa Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid) Artificial Cells, Nanomedicine, and Biotechnology Nanodiscs biomimetic drug delivery propolis styrene maleic acid nanoencapsulation |
| title | Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid) |
| title_full | Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid) |
| title_fullStr | Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid) |
| title_full_unstemmed | Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid) |
| title_short | Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid) |
| title_sort | encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly styrene alt maleic acid |
| topic | Nanodiscs biomimetic drug delivery propolis styrene maleic acid nanoencapsulation |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2023.2198570 |
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