Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay
Background: Development of biomarkers for autism spectrum disorder (ASD) has still remained a challenge to date. Recently, alterations of the expression of microRNAs (miRNAs) in peripheral blood, serum and post-mortem brain tissue have been linked to ASD. miRNAs are known to be secreted by various c...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2017-03-01
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| Series: | Folia Medica |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/folmed.2017.59.issue-1/folmed-2017-0009/folmed-2017-0009.xml?format=INT |
| _version_ | 1818234832972414976 |
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| author | Kichukova Tatyana M. Popov Nikolay T. Ivanov Ivan S. Vachev Tihomir I. |
| author_facet | Kichukova Tatyana M. Popov Nikolay T. Ivanov Ivan S. Vachev Tihomir I. |
| author_sort | Kichukova Tatyana M. |
| collection | DOAJ |
| description | Background: Development of biomarkers for autism spectrum disorder (ASD) has still remained a challenge to date. Recently, alterations of the expression of microRNAs (miRNAs) in peripheral blood, serum and post-mortem brain tissue have been linked to ASD. miRNAs are known to be secreted by various cell types and can mediate transmission of information into recipient cells and to modulate their physiological functions. On this basis it is assumed that circulating miRNAs could be useful biomarkers for the diagnosis or prognosis of pathological conditions. |
| first_indexed | 2024-12-12T11:44:21Z |
| format | Article |
| id | doaj.art-22e454a899654c06b72b5d0afcc161b8 |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-12-12T11:44:21Z |
| publishDate | 2017-03-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-22e454a899654c06b72b5d0afcc161b82022-12-22T00:25:28ZengPensoft PublishersFolia Medica1314-21432017-03-01591435210.1515/folmed-2017-0009folmed-2017-0009Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR AssayKichukova Tatyana M.0Popov Nikolay T.1Ivanov Ivan S.2Vachev Tihomir I.3Department of Plant Physiology and Molecular Biology, The “Paisii Hilendarski” University of Plovdiv, 24 “Tzar Assen” St., 4000 Plovdiv, BulgariaMale psychiatric ward, State Psychiatric Hospital, Pazardzhik, BulgariaSt George University Hospital, Medical University, Plovdiv, Bulgaria BulgariaDepartment of Plant Physiology and Molecular Biology, The “Paisii Hilendarski” University of Plovdiv, 24 “Tzar Assen” St., 4000 Plovdiv, Bulgaria BulgariaBackground: Development of biomarkers for autism spectrum disorder (ASD) has still remained a challenge to date. Recently, alterations of the expression of microRNAs (miRNAs) in peripheral blood, serum and post-mortem brain tissue have been linked to ASD. miRNAs are known to be secreted by various cell types and can mediate transmission of information into recipient cells and to modulate their physiological functions. On this basis it is assumed that circulating miRNAs could be useful biomarkers for the diagnosis or prognosis of pathological conditions.http://www.degruyter.com/view/j/folmed.2017.59.issue-1/folmed-2017-0009/folmed-2017-0009.xml?format=INTautism spectrum disordermiRNAsstem-loop qRT-PCRserum |
| spellingShingle | Kichukova Tatyana M. Popov Nikolay T. Ivanov Ivan S. Vachev Tihomir I. Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay Folia Medica autism spectrum disorder miRNAs stem-loop qRT-PCR serum |
| title | Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay |
| title_full | Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay |
| title_fullStr | Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay |
| title_full_unstemmed | Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay |
| title_short | Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay |
| title_sort | profiling of circulating serum micrornas in children with autism spectrum disorder using stem loop qrt pcr assay |
| topic | autism spectrum disorder miRNAs stem-loop qRT-PCR serum |
| url | http://www.degruyter.com/view/j/folmed.2017.59.issue-1/folmed-2017-0009/folmed-2017-0009.xml?format=INT |
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