Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients?
Objective:Triple negative breast cancer (TNBC) has a higher proportion of patients with distant recurrence or metastasis. Ki-67 has been suggested as an essential factor in cancer grading and prognostic evaluation, although there is still a debate regarding the Ki-67 cut-off value in TNBC. The aim o...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-10-01
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| Series: | European Journal of Breast Health |
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| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/does-a-40-cut-off-point-for-ki-67-expression-have-/62265
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| _version_ | 1797666560658112512 |
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| author | Kelvin Setiawan Ida Bagus Suryawisesa I Ketut Widiana I Wayan Sudarsa |
| author_facet | Kelvin Setiawan Ida Bagus Suryawisesa I Ketut Widiana I Wayan Sudarsa |
| author_sort | Kelvin Setiawan |
| collection | DOAJ |
| description | Objective:Triple negative breast cancer (TNBC) has a higher proportion of patients with distant recurrence or metastasis. Ki-67 has been suggested as an essential factor in cancer grading and prognostic evaluation, although there is still a debate regarding the Ki-67 cut-off value in TNBC. The aim of this study was to determine the role of Ki-67 expression using a 40% cut-off point as a risk factor for developing distant metastasis within two years in patients with TNBC.Materials and Methods:This analytical observational study was conducted with a case-control design from January 2021-2022. Subjects were divided into two groups (metastasis within two years or more than two years after diagnosis). Bivariate analysis was conducted using chi-square test and odds ratio (OR) was also analyzed.Results:A total of 66 subjects were included. In patients with metastasized TNBC and a Ki-67 expression of ≥40%, 29 patients (55.8%) had metastasis occurring in ≤2 years and 23 patients (44.2%) had metastasis occurring in >2 years; in patients with metastasized TNBC and a Ki-67 expression of <40%, 4 patients (28.6%) had metastasis occurring in ≤2 years and 10 patients (71.4%) had metastasis occurring in >2 years. Chi-square analysis (p = 0.071) indicated no significant association between patients with Ki-67 expression of ≥40% and <40% with metastasis within 2 years [OR 3.152 (confidence interval: 95% 0.875–11.362)].Conclusion:Ki-67 protein expression of over 40% in patients with locally-advanced TNBC does not indicate a greater risk of distant metastasis in the first two years after diagnosis. |
| first_indexed | 2024-03-11T20:00:10Z |
| format | Article |
| id | doaj.art-22e4c928348e4d318651e36f0bedbc97 |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-03-11T20:00:10Z |
| publishDate | 2023-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-22e4c928348e4d318651e36f0bedbc972023-10-04T08:29:21ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312023-10-0119427427810.4274/ejbh.galenos.2023.2023-4-513049054Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients?Kelvin Setiawan0Ida Bagus Suryawisesa1I Ketut Widiana2I Wayan Sudarsa3 Department of General Surgery, Udayana University Faculty of Medicine, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali, Indonesia Division of Oncology Surgery, Department of Surgery, Udayana University Faculty of Medicine, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali, Indonesia Division of Oncology Surgery, Department of Surgery, Udayana University Faculty of Medicine, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali, Indonesia Division of Oncology Surgery, Department of Surgery, Udayana University Faculty of Medicine, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali, Indonesia Objective:Triple negative breast cancer (TNBC) has a higher proportion of patients with distant recurrence or metastasis. Ki-67 has been suggested as an essential factor in cancer grading and prognostic evaluation, although there is still a debate regarding the Ki-67 cut-off value in TNBC. The aim of this study was to determine the role of Ki-67 expression using a 40% cut-off point as a risk factor for developing distant metastasis within two years in patients with TNBC.Materials and Methods:This analytical observational study was conducted with a case-control design from January 2021-2022. Subjects were divided into two groups (metastasis within two years or more than two years after diagnosis). Bivariate analysis was conducted using chi-square test and odds ratio (OR) was also analyzed.Results:A total of 66 subjects were included. In patients with metastasized TNBC and a Ki-67 expression of ≥40%, 29 patients (55.8%) had metastasis occurring in ≤2 years and 23 patients (44.2%) had metastasis occurring in >2 years; in patients with metastasized TNBC and a Ki-67 expression of <40%, 4 patients (28.6%) had metastasis occurring in ≤2 years and 10 patients (71.4%) had metastasis occurring in >2 years. Chi-square analysis (p = 0.071) indicated no significant association between patients with Ki-67 expression of ≥40% and <40% with metastasis within 2 years [OR 3.152 (confidence interval: 95% 0.875–11.362)].Conclusion:Ki-67 protein expression of over 40% in patients with locally-advanced TNBC does not indicate a greater risk of distant metastasis in the first two years after diagnosis. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/does-a-40-cut-off-point-for-ki-67-expression-have-/62265 triple negative breast cancerbreast cancerki-67metastasis |
| spellingShingle | Kelvin Setiawan Ida Bagus Suryawisesa I Ketut Widiana I Wayan Sudarsa Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients? European Journal of Breast Health triple negative breast cancer breast cancer ki-67 metastasis |
| title | Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients? |
| title_full | Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients? |
| title_fullStr | Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients? |
| title_full_unstemmed | Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients? |
| title_short | Does a 40% Cut-off Point for Ki-67 Expression Have a Role in Identifying the Development of Distant Metastasis Within 2 Years in Locally Advanced Triple Negative Breast Cancer Patients? |
| title_sort | does a 40 cut off point for ki 67 expression have a role in identifying the development of distant metastasis within 2 years in locally advanced triple negative breast cancer patients |
| topic | triple negative breast cancer breast cancer ki-67 metastasis |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/does-a-40-cut-off-point-for-ki-67-expression-have-/62265
|
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