Response of the mosquito immune system and symbiotic bacteria to pathogen infection
Abstract Mosquitoes are the deadliest animal in the word, transmitting a variety of insect-borne infectious diseases, such as malaria, dengue fever, yellow fever, and Zika, causing more deaths than any other vector-borne pathogen. Moreover, in the absence of effective drugs and vaccines to prevent a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-024-06161-4 |
| _version_ | 1797275668081278976 |
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| author | Manjin Li Yang Zhou Jin Cheng Yiqing Wang Cejie Lan Yuan Shen |
| author_facet | Manjin Li Yang Zhou Jin Cheng Yiqing Wang Cejie Lan Yuan Shen |
| author_sort | Manjin Li |
| collection | DOAJ |
| description | Abstract Mosquitoes are the deadliest animal in the word, transmitting a variety of insect-borne infectious diseases, such as malaria, dengue fever, yellow fever, and Zika, causing more deaths than any other vector-borne pathogen. Moreover, in the absence of effective drugs and vaccines to prevent and treat insect-borne diseases, mosquito control is particularly important as the primary measure. In recent decades, due to the gradual increase in mosquito resistance, increasing attention has fallen on the mechanisms and effects associated with pathogen infection. This review provides an overview of mosquito innate immune mechanisms in terms of physical and physiological barriers, pattern recognition receptors, signalling pathways, and cellular and humoral immunity, as well as the antipathogenic effects of mosquito symbiotic bacteria. This review contributes to an in-depth understanding of the interaction process between mosquitoes and pathogens and provides a theoretical basis for biological defence strategies against mosquito-borne infectious diseases. Graphical Abstract |
| first_indexed | 2024-03-07T15:16:48Z |
| format | Article |
| id | doaj.art-22e508034dc14f99b039afa537910ab6 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-03-07T15:16:48Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-22e508034dc14f99b039afa537910ab62024-03-05T17:50:59ZengBMCParasites & Vectors1756-33052024-02-0117112010.1186/s13071-024-06161-4Response of the mosquito immune system and symbiotic bacteria to pathogen infectionManjin Li0Yang Zhou1Jin Cheng2Yiqing Wang3Cejie Lan4Yuan Shen5The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and PreventionNanjing Medical UniversityThe Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and PreventionThe Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and PreventionThe Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and PreventionThe Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and PreventionAbstract Mosquitoes are the deadliest animal in the word, transmitting a variety of insect-borne infectious diseases, such as malaria, dengue fever, yellow fever, and Zika, causing more deaths than any other vector-borne pathogen. Moreover, in the absence of effective drugs and vaccines to prevent and treat insect-borne diseases, mosquito control is particularly important as the primary measure. In recent decades, due to the gradual increase in mosquito resistance, increasing attention has fallen on the mechanisms and effects associated with pathogen infection. This review provides an overview of mosquito innate immune mechanisms in terms of physical and physiological barriers, pattern recognition receptors, signalling pathways, and cellular and humoral immunity, as well as the antipathogenic effects of mosquito symbiotic bacteria. This review contributes to an in-depth understanding of the interaction process between mosquitoes and pathogens and provides a theoretical basis for biological defence strategies against mosquito-borne infectious diseases. Graphical Abstracthttps://doi.org/10.1186/s13071-024-06161-4MosquitoPathogen infectionInnate immune systemImmune primingSymbiotic bacteria |
| spellingShingle | Manjin Li Yang Zhou Jin Cheng Yiqing Wang Cejie Lan Yuan Shen Response of the mosquito immune system and symbiotic bacteria to pathogen infection Parasites & Vectors Mosquito Pathogen infection Innate immune system Immune priming Symbiotic bacteria |
| title | Response of the mosquito immune system and symbiotic bacteria to pathogen infection |
| title_full | Response of the mosquito immune system and symbiotic bacteria to pathogen infection |
| title_fullStr | Response of the mosquito immune system and symbiotic bacteria to pathogen infection |
| title_full_unstemmed | Response of the mosquito immune system and symbiotic bacteria to pathogen infection |
| title_short | Response of the mosquito immune system and symbiotic bacteria to pathogen infection |
| title_sort | response of the mosquito immune system and symbiotic bacteria to pathogen infection |
| topic | Mosquito Pathogen infection Innate immune system Immune priming Symbiotic bacteria |
| url | https://doi.org/10.1186/s13071-024-06161-4 |
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