Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung Cancer
Lung cancer is the leading cause of cancer-related death worldwide. Metabolic reprogramming is a fundamental trait associated with lung cancer development that fuels tumor proliferation and survival. Monitoring such metabolic pathways and their intermediate metabolites can provide new avenues concer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/10/1037 |
| _version_ | 1797572982594338816 |
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| author | Atiah H. Almalki |
| author_facet | Atiah H. Almalki |
| author_sort | Atiah H. Almalki |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer-related death worldwide. Metabolic reprogramming is a fundamental trait associated with lung cancer development that fuels tumor proliferation and survival. Monitoring such metabolic pathways and their intermediate metabolites can provide new avenues concerning treatment strategies, and the identification of prognostic biomarkers that could be utilized to monitor drug responses in clinical practice. In this review, recent trends in the analytical techniques used for metabolome mapping of lung cancer are capitalized. These techniques include nuclear magnetic resonance (NMR), gas chromatography–mass spectrometry (GC-MS), liquid chromatography–mass spectrometry (LC-MS), and imaging mass spectrometry (MSI). The advantages and limitations of the application of each technique for monitoring the metabolite class or type are also highlighted. Moreover, their potential applications in the analysis of many biological samples will be evaluated. |
| first_indexed | 2024-03-10T21:03:16Z |
| format | Article |
| id | doaj.art-22e65987c1db43218f1249fdcb90b268 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T21:03:16Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-22e65987c1db43218f1249fdcb90b2682023-11-19T17:19:33ZengMDPI AGMetabolites2218-19892023-09-011310103710.3390/metabo13101037Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung CancerAtiah H. Almalki0Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaLung cancer is the leading cause of cancer-related death worldwide. Metabolic reprogramming is a fundamental trait associated with lung cancer development that fuels tumor proliferation and survival. Monitoring such metabolic pathways and their intermediate metabolites can provide new avenues concerning treatment strategies, and the identification of prognostic biomarkers that could be utilized to monitor drug responses in clinical practice. In this review, recent trends in the analytical techniques used for metabolome mapping of lung cancer are capitalized. These techniques include nuclear magnetic resonance (NMR), gas chromatography–mass spectrometry (GC-MS), liquid chromatography–mass spectrometry (LC-MS), and imaging mass spectrometry (MSI). The advantages and limitations of the application of each technique for monitoring the metabolite class or type are also highlighted. Moreover, their potential applications in the analysis of many biological samples will be evaluated.https://www.mdpi.com/2218-1989/13/10/1037metabolomicslung cancerNMRGC-MSLC-MSMSI |
| spellingShingle | Atiah H. Almalki Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung Cancer Metabolites metabolomics lung cancer NMR GC-MS LC-MS MSI |
| title | Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung Cancer |
| title_full | Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung Cancer |
| title_fullStr | Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung Cancer |
| title_full_unstemmed | Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung Cancer |
| title_short | Recent Analytical Advances for Decoding Metabolic Reprogramming in Lung Cancer |
| title_sort | recent analytical advances for decoding metabolic reprogramming in lung cancer |
| topic | metabolomics lung cancer NMR GC-MS LC-MS MSI |
| url | https://www.mdpi.com/2218-1989/13/10/1037 |
| work_keys_str_mv | AT atiahhalmalki recentanalyticaladvancesfordecodingmetabolicreprogramminginlungcancer |