Modeling functional changes to Escherichia coli thymidylate synthase upon single residue replacements: a structure-based approach
Escherichia coli thymidylate synthase (TS) is an enzyme that is indispensable to DNA synthesis and cell division, as it provides the only de novo source of dTMP by catalyzing the reductive methylation of dUMP, thus making it a key target for chemotherapeutic agents. High resolution X-ray crystallogr...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2015-01-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/721.pdf |