On histamine and appetites
Brain histamine may influence a variety of different behavioral and physiological functions, but its responsibility in waking up has casted a long shadow on other important functions of this neurotransmitter. Here we review evidence indicating a central role of brain histamine in motivation, emphasi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00051/full |
| _version_ | 1811262895340650496 |
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| author | Fernando eTorrealba Maria Eugenia eRiveros Marco eContreras Jose Luis eValdes |
| author_facet | Fernando eTorrealba Maria Eugenia eRiveros Marco eContreras Jose Luis eValdes |
| author_sort | Fernando eTorrealba |
| collection | DOAJ |
| description | Brain histamine may influence a variety of different behavioral and physiological functions, but its responsibility in waking up has casted a long shadow on other important functions of this neurotransmitter. Here we review evidence indicating a central role of brain histamine in motivation, emphasizing its differential involvement in the appetitive and consummatory phases of motivated behaviors. We discuss the inputs that control the histaminergic neurons of the tuberomamillary nucleus of the hypothalamus, which determine the distinct role of these neurons in appetitive behavior, sleep/wake cycles and in food anticipatory activity. We review evidence supporting a dysfunction of histamine neurons and its cortical input in certain forms of decreased motivation (apathy). We finally discuss the relationship between the histamine system and drug addiction as a dysfunction of motivation. |
| first_indexed | 2024-04-12T19:35:00Z |
| format | Article |
| id | doaj.art-22e9b72085d14fc5ae1ea8526319e17c |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-04-12T19:35:00Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-22e9b72085d14fc5ae1ea8526319e17c2022-12-22T03:19:13ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372012-07-01610.3389/fnsys.2012.0005123471On histamine and appetitesFernando eTorrealba0Maria Eugenia eRiveros1Marco eContreras2Jose Luis eValdes3Pontificia Universidad Catolica de ChilePontificia Universidad Catolica de ChilePontificia Universidad Catolica de ChileUniversidad de ChileBrain histamine may influence a variety of different behavioral and physiological functions, but its responsibility in waking up has casted a long shadow on other important functions of this neurotransmitter. Here we review evidence indicating a central role of brain histamine in motivation, emphasizing its differential involvement in the appetitive and consummatory phases of motivated behaviors. We discuss the inputs that control the histaminergic neurons of the tuberomamillary nucleus of the hypothalamus, which determine the distinct role of these neurons in appetitive behavior, sleep/wake cycles and in food anticipatory activity. We review evidence supporting a dysfunction of histamine neurons and its cortical input in certain forms of decreased motivation (apathy). We finally discuss the relationship between the histamine system and drug addiction as a dysfunction of motivation.http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00051/fullApathyAppetiteHistamineMotivationAddictioninfralimbic cortex |
| spellingShingle | Fernando eTorrealba Maria Eugenia eRiveros Marco eContreras Jose Luis eValdes On histamine and appetites Frontiers in Systems Neuroscience Apathy Appetite Histamine Motivation Addiction infralimbic cortex |
| title | On histamine and appetites |
| title_full | On histamine and appetites |
| title_fullStr | On histamine and appetites |
| title_full_unstemmed | On histamine and appetites |
| title_short | On histamine and appetites |
| title_sort | on histamine and appetites |
| topic | Apathy Appetite Histamine Motivation Addiction infralimbic cortex |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00051/full |
| work_keys_str_mv | AT fernandoetorrealba onhistamineandappetites AT mariaeugeniaeriveros onhistamineandappetites AT marcoecontreras onhistamineandappetites AT joseluisevaldes onhistamineandappetites |