Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident
Background. Autoimmune thyroiditis (AIT) is a combined, polygenic, organspecific disease. The incidence rate of AIT has a tendency to increase throughout the world. There is an upward trend in morbidity in younger age groups. Circulating thyroid peroxidase antibodies are found in 10–15 % of apparen...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2019-05-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | http://iej.zaslavsky.com.ua/article/view/174814 |
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| author | I.A. Luzanchuk V.I. Kravchenko I.M. Andrusishina O.M. Golinko |
| author_facet | I.A. Luzanchuk V.I. Kravchenko I.M. Andrusishina O.M. Golinko |
| author_sort | I.A. Luzanchuk |
| collection | DOAJ |
| description | Background. Autoimmune thyroiditis (AIT) is a combined, polygenic, organspecific disease. The incidence rate of AIT has a tendency to increase throughout the world. There is an upward trend in morbidity in younger age groups. Circulating thyroid peroxidase antibodies are found in 10–15 % of apparently healthy euthyroid persons. The purpose of the study was to establish the macro and microelement status in patients with AIT among residents of districts of Kyiv region affected by the Chornobyl accident. Materials and methods. Sixtyone residents from the areas in Kyiv region affected by the Chornobyl accident were examined: 45 persons without thyroid pathology were included in the control group and 16 with AIT — in the experimental group. All patients with a thyroid dose of < 0.3 Gy — ≥ 1 Gy are participants of the cohort studies of UkrainianBelarusianAmerican project. The study of micro and macroelements was performed by atomic emission spectroscopy with inductively coupled plasma (Dzherelo2003) on Optima 2100 DV device (PerkinElmer, USA). Results. When studying thyroid status, the group of patients with AIT differed from the controls in terms of increased thyroid volume, high levels of thyroid peroxidase antibodies and thyroidstimulating hormone. Urinary iodine excretion median in the studied groups was not significantly different: in the control group, it was 65.0 µg/l, in the experimental group — 80.6 µg/l, indicating the presence of mild iodine deficiency. The examined patients with AIT had reduced (p < 0.01) magnesium level in the blood serum (the median value was 18.59 mg/l) compared to the control group. The assessment of the chances of correlation between AIT diagnosis and magnesium level below the median one (20.6 mg/l) in the total group of subjects was: odds ratio (OR) = 6.63 (95% confidence interval (CI) [1.73; 24.8]; p < 0.01). Conclusions. The existing diagnosis of AIT is reliably significant in patients with thyroid dose above median value (0.12 Gy)) in the total group of patients surveyed in the Kyiv region: OR = 4.1 (95% CI [1.2; 13.9]; p < 0.05). The odds ratio was highest with a combination of reduced magnesium content and increased thyroid radiation dose: OR = 25 (95% CI [3.16; 179.0]; p = 0.002). |
| first_indexed | 2024-12-20T23:11:59Z |
| format | Article |
| id | doaj.art-22ebbc50abb74023a3298699df9e7e34 |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-12-20T23:11:59Z |
| publishDate | 2019-05-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-22ebbc50abb74023a3298699df9e7e342022-12-21T19:23:43ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272019-05-0115429029710.22141/2224-0721.15.4.2019.174814174814Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accidentI.A. Luzanchuk0V.I. Kravchenko1I.M. Andrusishina2O.M. Golinko3MD, PhD, Research Fellow at the Department of epidemiology of endocrine diseases, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, Ukraine; e-mail: igorluz@bigmir.netMD, PhD, Professor, Head of department of epidemiology of endocrine diseases, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineMD, PhD, Laboratory оf analitic chemistry and monitoring of toxic substances, State Institution “Institute of Occupational Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, UkraineMD, PhD, Leading Researcher at the Department of complex toxicological and hygienic evaluation of medical products, perfumery and cosmetic products and consumer goods, State Enterprise “L.I. Medved Scientific Center of Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine”, Kyiv, UkraineBackground. Autoimmune thyroiditis (AIT) is a combined, polygenic, organspecific disease. The incidence rate of AIT has a tendency to increase throughout the world. There is an upward trend in morbidity in younger age groups. Circulating thyroid peroxidase antibodies are found in 10–15 % of apparently healthy euthyroid persons. The purpose of the study was to establish the macro and microelement status in patients with AIT among residents of districts of Kyiv region affected by the Chornobyl accident. Materials and methods. Sixtyone residents from the areas in Kyiv region affected by the Chornobyl accident were examined: 45 persons without thyroid pathology were included in the control group and 16 with AIT — in the experimental group. All patients with a thyroid dose of < 0.3 Gy — ≥ 1 Gy are participants of the cohort studies of UkrainianBelarusianAmerican project. The study of micro and macroelements was performed by atomic emission spectroscopy with inductively coupled plasma (Dzherelo2003) on Optima 2100 DV device (PerkinElmer, USA). Results. When studying thyroid status, the group of patients with AIT differed from the controls in terms of increased thyroid volume, high levels of thyroid peroxidase antibodies and thyroidstimulating hormone. Urinary iodine excretion median in the studied groups was not significantly different: in the control group, it was 65.0 µg/l, in the experimental group — 80.6 µg/l, indicating the presence of mild iodine deficiency. The examined patients with AIT had reduced (p < 0.01) magnesium level in the blood serum (the median value was 18.59 mg/l) compared to the control group. The assessment of the chances of correlation between AIT diagnosis and magnesium level below the median one (20.6 mg/l) in the total group of subjects was: odds ratio (OR) = 6.63 (95% confidence interval (CI) [1.73; 24.8]; p < 0.01). Conclusions. The existing diagnosis of AIT is reliably significant in patients with thyroid dose above median value (0.12 Gy)) in the total group of patients surveyed in the Kyiv region: OR = 4.1 (95% CI [1.2; 13.9]; p < 0.05). The odds ratio was highest with a combination of reduced magnesium content and increased thyroid radiation dose: OR = 25 (95% CI [3.16; 179.0]; p = 0.002).http://iej.zaslavsky.com.ua/article/view/174814iodine deficiencythyroid glandautoimmune thyroiditisiodine urine excretionmacro- and microelementsrelative risk of disease |
| spellingShingle | I.A. Luzanchuk V.I. Kravchenko I.M. Andrusishina O.M. Golinko Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident Mìžnarodnij Endokrinologìčnij Žurnal iodine deficiency thyroid gland autoimmune thyroiditis iodine urine excretion macro- and microelements relative risk of disease |
| title | Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident |
| title_full | Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident |
| title_fullStr | Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident |
| title_full_unstemmed | Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident |
| title_short | Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident |
| title_sort | study of macro and microelement status in autoimmune thyroiditis among residents of districts of kyiv region affected by the chornobyl accident |
| topic | iodine deficiency thyroid gland autoimmune thyroiditis iodine urine excretion macro- and microelements relative risk of disease |
| url | http://iej.zaslavsky.com.ua/article/view/174814 |
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