HLA alleles associated with asparaginase hypersensitivity in Chinese children
Abstract Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparagina...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-021-01201-3 |
| _version_ | 1828958274445115392 |
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| author | Gilbert T. Chua Jaime S. Rosa Duque Daniel Ka Leung Cheuk Alex Wing Kwan Leung Wilfred Hing Sang Wong Anthony Pak Yin Liu Pamela P. W. Lee Shau Yin Ha Alan Kwok Shing Chiang Marco Hok Kung Ho Wai Keung Chu Yuk Sing Chan Chun Wing Luk Alvin Siu Cheung Ling Mike Yat Wah Kwan Oscar Kuen Fong Yiu Ian Chi Kei Wong Yu Lung Lau Chi Kong Li Wing Hang Leung Godfrey Chi Fung Chan Patrick Ip Janette Kwok |
| author_facet | Gilbert T. Chua Jaime S. Rosa Duque Daniel Ka Leung Cheuk Alex Wing Kwan Leung Wilfred Hing Sang Wong Anthony Pak Yin Liu Pamela P. W. Lee Shau Yin Ha Alan Kwok Shing Chiang Marco Hok Kung Ho Wai Keung Chu Yuk Sing Chan Chun Wing Luk Alvin Siu Cheung Ling Mike Yat Wah Kwan Oscar Kuen Fong Yiu Ian Chi Kei Wong Yu Lung Lau Chi Kong Li Wing Hang Leung Godfrey Chi Fung Chan Patrick Ip Janette Kwok |
| author_sort | Gilbert T. Chua |
| collection | DOAJ |
| description | Abstract Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6–11.4, p < 0.01) were significantly associated with l-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p < 0.01)]. |
| first_indexed | 2024-12-14T08:44:40Z |
| format | Article |
| id | doaj.art-22ec7d0d993f4738b97a608d399cf9f6 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-14T08:44:40Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-22ec7d0d993f4738b97a608d399cf9f62022-12-21T23:09:11ZengBMCJournal of Hematology & Oncology1756-87222021-10-011411410.1186/s13045-021-01201-3HLA alleles associated with asparaginase hypersensitivity in Chinese childrenGilbert T. Chua0Jaime S. Rosa Duque1Daniel Ka Leung Cheuk2Alex Wing Kwan Leung3Wilfred Hing Sang Wong4Anthony Pak Yin Liu5Pamela P. W. Lee6Shau Yin Ha7Alan Kwok Shing Chiang8Marco Hok Kung Ho9Wai Keung Chu10Yuk Sing Chan11Chun Wing Luk12Alvin Siu Cheung Ling13Mike Yat Wah Kwan14Oscar Kuen Fong Yiu15Ian Chi Kei Wong16Yu Lung Lau17Chi Kong Li18Wing Hang Leung19Godfrey Chi Fung Chan20Patrick Ip21Janette Kwok22Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Hong Kong Children’s HospitalDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDivision of Transplantation and Immunogenetics, Department of Pathology, Queen Mary HospitalDivision of Transplantation and Immunogenetics, Department of Pathology, Queen Mary HospitalDepartment of Paediatrics and Adolescent Medicine, Hong Kong Children’s HospitalDepartment of Paediatrics and Adolescent Medicine, Hong Kong Children’s HospitalDepartment of Paediatrics and Adolescent Medicine, Princess Margaret HospitalDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongLaboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology ParkDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Hong Kong Children’s HospitalDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 1/F, New Clinical Building, Queen Mary Hospital, The University of Hong KongDivision of Transplantation and Immunogenetics, Department of Pathology, Queen Mary HospitalAbstract Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6–11.4, p < 0.01) were significantly associated with l-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p < 0.01)].https://doi.org/10.1186/s13045-021-01201-3Human leukocyte antigensAsparaginaseHypersensitivityAllergyChineseChildren |
| spellingShingle | Gilbert T. Chua Jaime S. Rosa Duque Daniel Ka Leung Cheuk Alex Wing Kwan Leung Wilfred Hing Sang Wong Anthony Pak Yin Liu Pamela P. W. Lee Shau Yin Ha Alan Kwok Shing Chiang Marco Hok Kung Ho Wai Keung Chu Yuk Sing Chan Chun Wing Luk Alvin Siu Cheung Ling Mike Yat Wah Kwan Oscar Kuen Fong Yiu Ian Chi Kei Wong Yu Lung Lau Chi Kong Li Wing Hang Leung Godfrey Chi Fung Chan Patrick Ip Janette Kwok HLA alleles associated with asparaginase hypersensitivity in Chinese children Journal of Hematology & Oncology Human leukocyte antigens Asparaginase Hypersensitivity Allergy Chinese Children |
| title | HLA alleles associated with asparaginase hypersensitivity in Chinese children |
| title_full | HLA alleles associated with asparaginase hypersensitivity in Chinese children |
| title_fullStr | HLA alleles associated with asparaginase hypersensitivity in Chinese children |
| title_full_unstemmed | HLA alleles associated with asparaginase hypersensitivity in Chinese children |
| title_short | HLA alleles associated with asparaginase hypersensitivity in Chinese children |
| title_sort | hla alleles associated with asparaginase hypersensitivity in chinese children |
| topic | Human leukocyte antigens Asparaginase Hypersensitivity Allergy Chinese Children |
| url | https://doi.org/10.1186/s13045-021-01201-3 |
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