Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
Background: Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotin...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021014663 |
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| author | Fatimoh Idowu Ojuade Olufunke Esan Olorundare Olatunde Babatunde Akanbi Saheed Olanrewaju Afolabi Anoka Ayembe Njan |
| author_facet | Fatimoh Idowu Ojuade Olufunke Esan Olorundare Olatunde Babatunde Akanbi Saheed Olanrewaju Afolabi Anoka Ayembe Njan |
| author_sort | Fatimoh Idowu Ojuade |
| collection | DOAJ |
| description | Background: Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats. Methods: Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15 min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase inhibition, lipase inhibition and histology of the organs were evaluated. Results: Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, low-density lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of the pancreatic tissue after treatment with AEPN. Conclusions: This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin–nicotinamide-induced type 2 diabetic rats. |
| first_indexed | 2024-12-19T21:53:56Z |
| format | Article |
| id | doaj.art-22ece84362cc4338a219ade5acb7522b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-19T21:53:56Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-22ece84362cc4338a219ade5acb7522b2022-12-21T20:04:19ZengElsevierHeliyon2405-84402021-06-0176e07363Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic ratsFatimoh Idowu Ojuade0Olufunke Esan Olorundare1Olatunde Babatunde Akanbi2Saheed Olanrewaju Afolabi3Anoka Ayembe Njan4Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ilorin, Kwara State, Nigeria; Corresponding author.Department of Pharmacology and Therapeutics, College of Health Sciences, University of Ilorin, Kwara State, NigeriaDepartment of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Kwara State, NigeriaDepartment of Pharmacology and Therapeutics, College of Health Sciences, University of Ilorin, Kwara State, NigeriaDepartment of Pharmacology and Therapeutics, College of Health Sciences, University of Ilorin, Kwara State, NigeriaBackground: Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats. Methods: Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15 min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase inhibition, lipase inhibition and histology of the organs were evaluated. Results: Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, low-density lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of the pancreatic tissue after treatment with AEPN. Conclusions: This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin–nicotinamide-induced type 2 diabetic rats.http://www.sciencedirect.com/science/article/pii/S2405844021014663AntioxidantDiabetesParquetina nigrescensStreptozotocinHistology |
| spellingShingle | Fatimoh Idowu Ojuade Olufunke Esan Olorundare Olatunde Babatunde Akanbi Saheed Olanrewaju Afolabi Anoka Ayembe Njan Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats Heliyon Antioxidant Diabetes Parquetina nigrescens Streptozotocin Histology |
| title | Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats |
| title_full | Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats |
| title_fullStr | Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats |
| title_full_unstemmed | Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats |
| title_short | Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats |
| title_sort | antidiabetic and antihyperlipidemic effects of aqueous extract of parquetina nigrescens in streptozotocin nicotinamide induced type 2 diabetic rats |
| topic | Antioxidant Diabetes Parquetina nigrescens Streptozotocin Histology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844021014663 |
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