Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitis
Abstract Feline infectious peritonitis (FIP) historically has been a fatal disease in cats. Recent unlicensed use of antiviral medication has been shown to markedly improve survival of this infection. An 8‐month‐old female spayed domestic short‐haired cat undergoing treatment for presumptive FIP wit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16954 |
| _version_ | 1797349484137545728 |
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| author | Marissa Allinder Beth Tynan Cara Martin Amelia Furbish Glenn Austin Joe Bartges Bianca N. Lourenço |
| author_facet | Marissa Allinder Beth Tynan Cara Martin Amelia Furbish Glenn Austin Joe Bartges Bianca N. Lourenço |
| author_sort | Marissa Allinder |
| collection | DOAJ |
| description | Abstract Feline infectious peritonitis (FIP) historically has been a fatal disease in cats. Recent unlicensed use of antiviral medication has been shown to markedly improve survival of this infection. An 8‐month‐old female spayed domestic short‐haired cat undergoing treatment for presumptive FIP with the antiviral nucleoside analog GS‐441524 developed acute progressive azotemia. Abdominal ultrasound examination identified multifocal urolithiasis including renal, ureteral, and cystic calculi. Unilateral ureteral obstruction progressed to suspected bilateral ureteral obstruction and subcutaneous ureteral bypass (SUB) was performed along with urolith removal and submission for analysis. A 2‐year‐old male neutered domestic medium‐haired cat undergoing treatment for confirmed FIP with GS‐441524 developed dysuria (weak urine stream, urinary incontinence, and difficulty expressing the urinary bladder). This cat also was diagnosed sonographically with multifocal urolithiasis requiring temporary tube cystostomy after cystotomy and urolith removal. In both cases, initial urolith analysis showed unidentified material. Additional testing confirmed the calculi in both cats to be 98% consistent with GS‐441524. Additional clinical studies are required to determine best screening practices for cats presented for urolithiasis during treatment with GS‐441524. |
| first_indexed | 2024-03-08T12:31:00Z |
| format | Article |
| id | doaj.art-22edc188e7f845d38e61b2f1939be325 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-03-08T12:31:00Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-22edc188e7f845d38e61b2f1939be3252024-01-22T02:05:50ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762024-01-0138137037410.1111/jvim.16954Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitisMarissa Allinder0Beth Tynan1Cara Martin2Amelia Furbish3Glenn Austin4Joe Bartges5Bianca N. Lourenço6Clinical Veterinary Pharmacy Charleston Veterinary Referral Center Charleston South Carolina USACritical Care Charleston Veterinary Referral Center Charleston South Carolina USASmall Animal Medicine and Surgery, College of Veterinary Medicine University of Georgia Athens Georgia USADept. of Drug Discovery and Biomedical Sciences, College of Pharmacy Medical University of South Carolina Charleston South Carolina USALouis C. Herring & Company Orlando Florida USASmall Animal Medicine and Surgery, College of Veterinary Medicine University of Georgia Athens Georgia USASmall Animal Medicine and Surgery, College of Veterinary Medicine University of Georgia Athens Georgia USAAbstract Feline infectious peritonitis (FIP) historically has been a fatal disease in cats. Recent unlicensed use of antiviral medication has been shown to markedly improve survival of this infection. An 8‐month‐old female spayed domestic short‐haired cat undergoing treatment for presumptive FIP with the antiviral nucleoside analog GS‐441524 developed acute progressive azotemia. Abdominal ultrasound examination identified multifocal urolithiasis including renal, ureteral, and cystic calculi. Unilateral ureteral obstruction progressed to suspected bilateral ureteral obstruction and subcutaneous ureteral bypass (SUB) was performed along with urolith removal and submission for analysis. A 2‐year‐old male neutered domestic medium‐haired cat undergoing treatment for confirmed FIP with GS‐441524 developed dysuria (weak urine stream, urinary incontinence, and difficulty expressing the urinary bladder). This cat also was diagnosed sonographically with multifocal urolithiasis requiring temporary tube cystostomy after cystotomy and urolith removal. In both cases, initial urolith analysis showed unidentified material. Additional testing confirmed the calculi in both cats to be 98% consistent with GS‐441524. Additional clinical studies are required to determine best screening practices for cats presented for urolithiasis during treatment with GS‐441524.https://doi.org/10.1111/jvim.16954antiviralscoronavirusfelinefipGS‐441524urolith |
| spellingShingle | Marissa Allinder Beth Tynan Cara Martin Amelia Furbish Glenn Austin Joe Bartges Bianca N. Lourenço Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitis Journal of Veterinary Internal Medicine antivirals coronavirus feline fip GS‐441524 urolith |
| title | Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitis |
| title_full | Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitis |
| title_fullStr | Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitis |
| title_full_unstemmed | Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitis |
| title_short | Uroliths composed of antiviral compound GS‐441524 in 2 cats undergoing treatment for feline infectious peritonitis |
| title_sort | uroliths composed of antiviral compound gs 441524 in 2 cats undergoing treatment for feline infectious peritonitis |
| topic | antivirals coronavirus feline fip GS‐441524 urolith |
| url | https://doi.org/10.1111/jvim.16954 |
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