Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis
<b>: </b>Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) and other kidney-related biomarkers were...
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MDPI AG
2020-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/7/439 |
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| author | Haorile Chagan-Yasutan Firmanto Hanan Toshiro Niki Gaowa Bai Yugo Ashino Shinichi Egawa Elizabeth Freda O. Telan Toshio Hattori |
| author_facet | Haorile Chagan-Yasutan Firmanto Hanan Toshiro Niki Gaowa Bai Yugo Ashino Shinichi Egawa Elizabeth Freda O. Telan Toshio Hattori |
| author_sort | Haorile Chagan-Yasutan |
| collection | DOAJ |
| description | <b>: </b>Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) and other kidney-related biomarkers were measured to understand the pathological and diagnostic roles of OPN and Gal-9 in leptospirosis. Plasma levels of full-length (FL)-OPN (pFL-OPN) (<i>p</i><i> </i>< 0.0001), pFL-Gal-9(<i>p</i><i> </i>< 0.0001) and thrombin-cleaved OPN (<i>p</i><i> </i>< 0.01) were significantly higher in patients with leptospirosis than in healthy controls (<i>n</i> = 30), as were levels of several indicators of renal toxicity: serum cystatin C (<i>p</i><i> </i>< 0.0001), urine <i>N</i>-acetyl-β-glucosaminidase (NAG)/creatinine (<i>p</i><i> </i>< 0.05), and urine clusterin/creatinine (<i>p</i><i> </i>< 0.05). pFL-Gal-9 levels were negatively correlated with pFL-OPN levels (<i>r</i> = −0.24, <i>p</i><i> </i>< 0.05). pFL-OPN levels were positively correlated with serum cystatin C (<i>r</i> = 0.41, <i>p</i> < 0.0001), urine NAG/creatinine (<i>r </i>= 0.35, <i>p</i><i> </i>< 0.001), urine clusterin/creatinine (<i>r</i> = 0.33, <i>p</i><i> </i>< 0.01), and urine cystatin C/creatinine (<i>r</i> = 0.33, <i>p</i><i> </i>< 0.05) levels. In a group of patients with abnormally high creatinine levels, significantly higher levels of serum cystatin C (<i>p</i> < 0.0001) and pFL-OPN (<i>p</i> < 0.001) were observed. Our results demonstrate that pFL-OPN reflect kidney injury among patients with leptospirosis. |
| first_indexed | 2024-03-10T18:49:07Z |
| format | Article |
| id | doaj.art-22ef1f3e8a7649cb91af67d62da3e344 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T18:49:07Z |
| publishDate | 2020-06-01 |
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| series | Diagnostics |
| spelling | doaj.art-22ef1f3e8a7649cb91af67d62da3e3442023-11-20T05:14:33ZengMDPI AGDiagnostics2075-44182020-06-0110743910.3390/diagnostics10070439Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with LeptospirosisHaorile Chagan-Yasutan0Firmanto Hanan1Toshiro Niki2Gaowa Bai3Yugo Ashino4Shinichi Egawa5Elizabeth Freda O. Telan6Toshio Hattori7Department of Health Science and Social Welfare, Kibi International University, 8 Igamachi, Takahashi 716-8508, JapanDisease Control and Prevention Division of Banyuasin District Health Office, Pangkalan Balai, South Sumatra 30753, IndonesiaDepartment of Immunology, Faculty of Medicine, Kagawa University, Kita-gun 761-0793, JapanDepartment of Health Science and Social Welfare, Kibi International University, 8 Igamachi, Takahashi 716-8508, JapanDepartment of Respiratory Medicine, Sendai City Hospital, Miyagi 982-8502, JapanInternational Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, JapanNational Reference Laboratory for HIV/AIDS, Hepatitis, and other STDs, STD/AIDS Cooperative Central Laboratory, Manila 1003, PhilippinesDepartment of Health Science and Social Welfare, Kibi International University, 8 Igamachi, Takahashi 716-8508, Japan<b>: </b>Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) and other kidney-related biomarkers were measured to understand the pathological and diagnostic roles of OPN and Gal-9 in leptospirosis. Plasma levels of full-length (FL)-OPN (pFL-OPN) (<i>p</i><i> </i>< 0.0001), pFL-Gal-9(<i>p</i><i> </i>< 0.0001) and thrombin-cleaved OPN (<i>p</i><i> </i>< 0.01) were significantly higher in patients with leptospirosis than in healthy controls (<i>n</i> = 30), as were levels of several indicators of renal toxicity: serum cystatin C (<i>p</i><i> </i>< 0.0001), urine <i>N</i>-acetyl-β-glucosaminidase (NAG)/creatinine (<i>p</i><i> </i>< 0.05), and urine clusterin/creatinine (<i>p</i><i> </i>< 0.05). pFL-Gal-9 levels were negatively correlated with pFL-OPN levels (<i>r</i> = −0.24, <i>p</i><i> </i>< 0.05). pFL-OPN levels were positively correlated with serum cystatin C (<i>r</i> = 0.41, <i>p</i> < 0.0001), urine NAG/creatinine (<i>r </i>= 0.35, <i>p</i><i> </i>< 0.001), urine clusterin/creatinine (<i>r</i> = 0.33, <i>p</i><i> </i>< 0.01), and urine cystatin C/creatinine (<i>r</i> = 0.33, <i>p</i><i> </i>< 0.05) levels. In a group of patients with abnormally high creatinine levels, significantly higher levels of serum cystatin C (<i>p</i> < 0.0001) and pFL-OPN (<i>p</i> < 0.001) were observed. Our results demonstrate that pFL-OPN reflect kidney injury among patients with leptospirosis.https://www.mdpi.com/2075-4418/10/7/439leptospirosisbiomarkerosteopontingalectin-9cystatin Cclusterin |
| spellingShingle | Haorile Chagan-Yasutan Firmanto Hanan Toshiro Niki Gaowa Bai Yugo Ashino Shinichi Egawa Elizabeth Freda O. Telan Toshio Hattori Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis Diagnostics leptospirosis biomarker osteopontin galectin-9 cystatin C clusterin |
| title | Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis |
| title_full | Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis |
| title_fullStr | Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis |
| title_full_unstemmed | Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis |
| title_short | Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis |
| title_sort | plasma osteopontin levels is associated with biochemical markers of kidney injury in patients with leptospirosis |
| topic | leptospirosis biomarker osteopontin galectin-9 cystatin C clusterin |
| url | https://www.mdpi.com/2075-4418/10/7/439 |
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