Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors

Metaplastic breast carcinoma (MBC) is among the most aggressive subtypes of triple-negative breast cancer (TNBC) but the underlying proteome profiles are unknown. Here, the authors characterize the protein signatures of human MBC tissue samples and their relationship to TNBC and normal breast tissue...

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Main Authors: Sabra I. Djomehri, Maria E. Gonzalez, Felipe da Veiga Leprevost, Shilpa R. Tekula, Hui-Yin Chang, Marissa J. White, Ashley Cimino-Mathews, Boris Burman, Venkatesha Basrur, Pedram Argani, Alexey I. Nesvizhskii, Celina G. Kleer
Format: Article
Language:English
Published: Nature Portfolio 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15283-z
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author Sabra I. Djomehri
Maria E. Gonzalez
Felipe da Veiga Leprevost
Shilpa R. Tekula
Hui-Yin Chang
Marissa J. White
Ashley Cimino-Mathews
Boris Burman
Venkatesha Basrur
Pedram Argani
Alexey I. Nesvizhskii
Celina G. Kleer
author_facet Sabra I. Djomehri
Maria E. Gonzalez
Felipe da Veiga Leprevost
Shilpa R. Tekula
Hui-Yin Chang
Marissa J. White
Ashley Cimino-Mathews
Boris Burman
Venkatesha Basrur
Pedram Argani
Alexey I. Nesvizhskii
Celina G. Kleer
author_sort Sabra I. Djomehri
collection DOAJ
description Metaplastic breast carcinoma (MBC) is among the most aggressive subtypes of triple-negative breast cancer (TNBC) but the underlying proteome profiles are unknown. Here, the authors characterize the protein signatures of human MBC tissue samples and their relationship to TNBC and normal breast tissue.
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spelling doaj.art-22ef73a0f75440e0a22ac00ea2373d422022-12-21T21:53:52ZengNature PortfolioNature Communications2041-17232020-04-0111111510.1038/s41467-020-15283-zQuantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumorsSabra I. Djomehri0Maria E. Gonzalez1Felipe da Veiga Leprevost2Shilpa R. Tekula3Hui-Yin Chang4Marissa J. White5Ashley Cimino-Mathews6Boris Burman7Venkatesha Basrur8Pedram Argani9Alexey I. Nesvizhskii10Celina G. Kleer11Department of Pathology, University of Michigan Medical SchoolDepartment of Pathology, University of Michigan Medical SchoolDepartment of Pathology, University of Michigan Medical SchoolDepartment of Pathology, University of Michigan Medical SchoolDepartment of Pathology, University of Michigan Medical SchoolDepartment of Pathology, Johns Hopkins UniversityDepartment of Pathology, Johns Hopkins UniversityDepartment of Pathology, University of Michigan Medical SchoolDepartment of Pathology, University of Michigan Medical SchoolDepartment of Pathology, Johns Hopkins UniversityDepartment of Pathology, University of Michigan Medical SchoolDepartment of Pathology, University of Michigan Medical SchoolMetaplastic breast carcinoma (MBC) is among the most aggressive subtypes of triple-negative breast cancer (TNBC) but the underlying proteome profiles are unknown. Here, the authors characterize the protein signatures of human MBC tissue samples and their relationship to TNBC and normal breast tissue.https://doi.org/10.1038/s41467-020-15283-z
spellingShingle Sabra I. Djomehri
Maria E. Gonzalez
Felipe da Veiga Leprevost
Shilpa R. Tekula
Hui-Yin Chang
Marissa J. White
Ashley Cimino-Mathews
Boris Burman
Venkatesha Basrur
Pedram Argani
Alexey I. Nesvizhskii
Celina G. Kleer
Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
Nature Communications
title Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
title_full Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
title_fullStr Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
title_full_unstemmed Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
title_short Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors
title_sort quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple negative tumors
url https://doi.org/10.1038/s41467-020-15283-z
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