High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents

High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents

Boron cluster-modified therapeutic nucleic acids with improved properties are of interest in gene therapy and in cancer boron neutron capture therapy (BNCT). High metallacarborane-loaded antisense oligonucleotides (ASOs) targeting epidermal growth factor receptor (EGFR) were synthesized through post...

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Bibliographic Details
Main Authors: Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Milena Sobczak, Błażej Wojtczak, Sławomir Janczak, Zbigniew J. Leśnikowski, Barbara Nawrot
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
metallacarborane
antisense oligonucleotide
BNCT
ROS
EGFR
Online Access:https://www.mdpi.com/1420-3049/22/9/1393

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