RISK FACTORS FOR METABOLIC SYNDROME IN OBESE CHILDREN
Obesity and closely associated metabolic syndrome develop under the influence of a combination of genetic and environmental factors and are a challenging problem in the present-day pediatrics.Objective of the study: determination of the significant risk factors causing the formation of metabolic sy...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2018-06-01
|
| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/675 |
| Summary: | Obesity and closely associated metabolic syndrome develop under the influence of a combination of genetic and environmental factors and are a challenging problem in the present-day pediatrics.Objective of the study: determination of the significant risk factors causing the formation of metabolic syndrome in childhood and their ranking according to the degree of etiological conditionality and manageability. 483 children aged 5–16 years were examined: 237 children who had metabolic syndrome, 246 children who did not. The complex study included a number of clinical laboratory and instrumental methods of study performed using the conventional methods. Methods of epidemiological statistics were used to calculate the relative (RR) and attributive (AR) risks, as well as the etiological fraction of relative risk (EF).Results. It has been established that risk factors for the development of metabolic syndrome with a very high and high degree of etiological conditionality which are difficult to control include abdominal (visceral) type of obesity, hyperglycemia, hypertriglyceridemia, those which are averagely difficult to control – lowering of high density lipoprotein cholesterol, hyperuricemia, and the controlled (conditionally controlled) factors include the body mass index more than 30 kg/m2, the duration of obesity of 5 and more years, the birth weight less than 2500 g, hepatobiliary disorders (non-alcoholic liver disease, biliary sludge, gallbladder cholesterosis), eating disorders in the form of a “night eating syndrome”, obesity either in the mother or both parents, mother’s or maternal grandmother’s type 2 diabetes. It has been proven that the timely initiation of therapy and prophylactic measures at the early stages of the disease, contributing to a reduction of the obesity degree and duration of the disease, allows to reduce the risk of forming metabolic syndrome in a child by 23%, improving maternal health and normalizing the body weight during the planning of pregnancy – by 22%.Conclusions. The analysis of genetic, physiological and social and economic factors enables assessing their contribution to the formation of metabolic syndrome and to classify the risk groups for its development. After classification of risk factors according to the degree of control the researchers can focus on a group of controlled factors and choose the most effective algorithms of therapeutic and preventive measures. |
|---|---|
| ISSN: | 1027-4065 2500-2228 |