Retinal diffusion restrictions in acute branch retinal arteriolar occlusion
Abstract This study sought to investigate the occurrence of retinal diffusion restrictions (RDR) in branch retinal arteriolar occlusion (BRAO) using standard brain diffusion-weighted imaging (DWI). Two radiologists assessed DWI MRI scans of BRAO patients for RDR in a retrospective cohort study. Inte...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-00127-7 |
| _version_ | 1818724703414517760 |
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| author | Leon Alexander Danyel M. Miszczuk K. Villringer G. Bohner E. Siebert |
| author_facet | Leon Alexander Danyel M. Miszczuk K. Villringer G. Bohner E. Siebert |
| author_sort | Leon Alexander Danyel |
| collection | DOAJ |
| description | Abstract This study sought to investigate the occurrence of retinal diffusion restrictions (RDR) in branch retinal arteriolar occlusion (BRAO) using standard brain diffusion-weighted imaging (DWI). Two radiologists assessed DWI MRI scans of BRAO patients for RDR in a retrospective cohort study. Inter- and intrarater reliability were calculated using Kappa statistics. Detection rates of RDR were compared among MRI scans with varying field strength, sequence type and onset-to-DWI time intervals. 85 BRAO patients (63.1 ± 16.5 years) and 89 DWI scans were evaluated. Overall sensitivity of RDR in BRAO was 46.1% with visually correlating low ADC signal in 56.1% of cases. Localization of RDR matched distribution of fundoscopic retinal edema in 85% of patients. Inter- and intra-rater agreement for RDR in BRAO was κinter = 0.64 (95% CI 0.48–0.80) and κintra = 0.87 (95% CI 0.76–0.96), respectively. RDR detection rate tended to be higher for 3T, when compared to 1.5T MRI scans (53.7% vs. 34.3%%; p = 0.07). RDR were identified within 24 h up to 2 weeks after onset of visual impairment. RDR in BRAO can be observed by means of standard stroke DWI in a substantial proportion of cases, although sensitivity and interrater reliability were lower than previously reported for complete central retinal artery occlusion. |
| first_indexed | 2024-12-17T21:30:38Z |
| format | Article |
| id | doaj.art-22f2460bc2a04c69a3f05b74066d46b9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T21:30:38Z |
| publishDate | 2021-10-01 |
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| series | Scientific Reports |
| spelling | doaj.art-22f2460bc2a04c69a3f05b74066d46b92022-12-21T21:31:53ZengNature PortfolioScientific Reports2045-23222021-10-011111610.1038/s41598-021-00127-7Retinal diffusion restrictions in acute branch retinal arteriolar occlusionLeon Alexander Danyel0M. Miszczuk1K. Villringer2G. Bohner3E. Siebert4Department of Neurology, Charité-Universitätsmedizin BerlinInstitute for Neuroradiology, Charité-Universitätsmedizin BerlinCenter for Stroke Research Berlin, Charité-Universitätsmedizin BerlinInstitute for Neuroradiology, Charité-Universitätsmedizin BerlinInstitute for Neuroradiology, Charité-Universitätsmedizin BerlinAbstract This study sought to investigate the occurrence of retinal diffusion restrictions (RDR) in branch retinal arteriolar occlusion (BRAO) using standard brain diffusion-weighted imaging (DWI). Two radiologists assessed DWI MRI scans of BRAO patients for RDR in a retrospective cohort study. Inter- and intrarater reliability were calculated using Kappa statistics. Detection rates of RDR were compared among MRI scans with varying field strength, sequence type and onset-to-DWI time intervals. 85 BRAO patients (63.1 ± 16.5 years) and 89 DWI scans were evaluated. Overall sensitivity of RDR in BRAO was 46.1% with visually correlating low ADC signal in 56.1% of cases. Localization of RDR matched distribution of fundoscopic retinal edema in 85% of patients. Inter- and intra-rater agreement for RDR in BRAO was κinter = 0.64 (95% CI 0.48–0.80) and κintra = 0.87 (95% CI 0.76–0.96), respectively. RDR detection rate tended to be higher for 3T, when compared to 1.5T MRI scans (53.7% vs. 34.3%%; p = 0.07). RDR were identified within 24 h up to 2 weeks after onset of visual impairment. RDR in BRAO can be observed by means of standard stroke DWI in a substantial proportion of cases, although sensitivity and interrater reliability were lower than previously reported for complete central retinal artery occlusion.https://doi.org/10.1038/s41598-021-00127-7 |
| spellingShingle | Leon Alexander Danyel M. Miszczuk K. Villringer G. Bohner E. Siebert Retinal diffusion restrictions in acute branch retinal arteriolar occlusion Scientific Reports |
| title | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
| title_full | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
| title_fullStr | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
| title_full_unstemmed | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
| title_short | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
| title_sort | retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
| url | https://doi.org/10.1038/s41598-021-00127-7 |
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