Roles of Non-coding RNAs in Central Nervous System Axon Regeneration
Axons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to pr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.630633/full |
| _version_ | 1818413144536514560 |
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| author | Pei Li Yuanyuan Jia Wenbo Tang Qingjun Cui Ming Liu Jingjing Jiang |
| author_facet | Pei Li Yuanyuan Jia Wenbo Tang Qingjun Cui Ming Liu Jingjing Jiang |
| author_sort | Pei Li |
| collection | DOAJ |
| description | Axons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to promote the regeneration capability of injured nerves. Evidence has shown that non-coding RNAs play an essential role in nerve regeneration, especially long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). In this review, we profile their separate roles in axon regeneration after CNS injuries, such as spinal cord injury (SCI) and optic nerve injury. In addition, we also reveal the interactive networks among non-coding RNAs. |
| first_indexed | 2024-12-14T10:58:32Z |
| format | Article |
| id | doaj.art-22f26363b9ea4248aba700a89c139377 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T10:58:32Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-22f26363b9ea4248aba700a89c1393772022-12-21T23:04:50ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-02-011510.3389/fnins.2021.630633630633Roles of Non-coding RNAs in Central Nervous System Axon RegenerationPei LiYuanyuan JiaWenbo TangQingjun CuiMing LiuJingjing JiangAxons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to promote the regeneration capability of injured nerves. Evidence has shown that non-coding RNAs play an essential role in nerve regeneration, especially long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). In this review, we profile their separate roles in axon regeneration after CNS injuries, such as spinal cord injury (SCI) and optic nerve injury. In addition, we also reveal the interactive networks among non-coding RNAs.https://www.frontiersin.org/articles/10.3389/fnins.2021.630633/fullnon-coding RNAnerve regenerationcentral nervous systemoptic nerve injuryspinal cord injury |
| spellingShingle | Pei Li Yuanyuan Jia Wenbo Tang Qingjun Cui Ming Liu Jingjing Jiang Roles of Non-coding RNAs in Central Nervous System Axon Regeneration Frontiers in Neuroscience non-coding RNA nerve regeneration central nervous system optic nerve injury spinal cord injury |
| title | Roles of Non-coding RNAs in Central Nervous System Axon Regeneration |
| title_full | Roles of Non-coding RNAs in Central Nervous System Axon Regeneration |
| title_fullStr | Roles of Non-coding RNAs in Central Nervous System Axon Regeneration |
| title_full_unstemmed | Roles of Non-coding RNAs in Central Nervous System Axon Regeneration |
| title_short | Roles of Non-coding RNAs in Central Nervous System Axon Regeneration |
| title_sort | roles of non coding rnas in central nervous system axon regeneration |
| topic | non-coding RNA nerve regeneration central nervous system optic nerve injury spinal cord injury |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.630633/full |
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