The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis
Abstract Background: The close relationship between psoriasis and concomitant diseases is widely accepted. However, a comprehensive analysis of organ-based comorbidities in psoriasis is still lacking. Objective: The authors aimed to present the risk of organ-based comorbidities in psoriasis by com...
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Format: | Article |
Language: | English |
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Sociedade Brasileira de Dermatologia
2022-09-01
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Series: | Anais Brasileiros de Dermatologia |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500612&tlng=en |
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author | Xuemei Tang Ling Chen |
author_facet | Xuemei Tang Ling Chen |
author_sort | Xuemei Tang |
collection | DOAJ |
description | Abstract Background: The close relationship between psoriasis and concomitant diseases is widely accepted. However, a comprehensive analysis of organ-based comorbidities in psoriasis is still lacking. Objective: The authors aimed to present the risk of organ-based comorbidities in psoriasis by comparing the general population. Methods: The authors retrieved a search of Pubmed, EMBASE, and Cochrane databases for studies reporting organ-based comorbidities in psoriasis versus the general population. Observational studies that met the following criteria were assessed: 1) Psoriasis diagnosis; 2) Cardiovascular or kidney or liver or respiratory or cerebrovascular outcomes; 3) Comparison group of individuals without psoriasis. Pooled Relative Risks (pRRs) and 95% Confidence Intervals (CIs) were calculated by using the random-effect model. Results: Fifteen observational studies with 216,348 psoriatic patients and 9,896,962 individuals from the general population were included. Psoriasis showed a greater risk of organ-based comorbidities. Compared to the general population, pRR for all organ-based comorbidities was 1.20 (95% CI 1.11–1.31) in psoriasis, and pRR was lower in mild 0.61 (95% CI 0.46–0.81) than in moderate/severe patients. pRR was 1.20 (95% CI 1.11–1.30) for cardiovascular, 1.56 (95% CI 1.20–2.04), and 1.75 (95% CI 1.33–2.29) for cerebrovascular and liver diseases, respectively. pRR for coexisting renal and cardiovascular events was 1.09 (95% CI 1.01–1.18). pRR for coexisting renal and cerebrovascular events was 1.28 (95% CI 0.99–1.66). pRR for coexisting renal and liver diseases was 1.46 (95% CI 1.10–1.94). pRR for coexisting cardiovascular and liver diseases was 1.41 (95% CI 1.11–1.80). Study limitations: There is heterogeneity. Conclusion: Psoriasis has a higher risk of single and multiple organ-based comorbidities than the general population. The present study will further improve attention to psoriasis as a systemic inflammatory disease. |
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format | Article |
id | doaj.art-22f38374e3d74141b48fd22afd93aaaf |
institution | Directory Open Access Journal |
issn | 0365-0596 |
language | English |
last_indexed | 2024-04-11T09:20:04Z |
publishDate | 2022-09-01 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | Article |
series | Anais Brasileiros de Dermatologia |
spelling | doaj.art-22f38374e3d74141b48fd22afd93aaaf2022-12-22T04:32:13ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962022-09-0197561262310.1016/j.abd.2021.10.007The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysisXuemei Tanghttps://orcid.org/0000-0002-6844-3188Ling Chenhttps://orcid.org/0000-0003-1485-1626Abstract Background: The close relationship between psoriasis and concomitant diseases is widely accepted. However, a comprehensive analysis of organ-based comorbidities in psoriasis is still lacking. Objective: The authors aimed to present the risk of organ-based comorbidities in psoriasis by comparing the general population. Methods: The authors retrieved a search of Pubmed, EMBASE, and Cochrane databases for studies reporting organ-based comorbidities in psoriasis versus the general population. Observational studies that met the following criteria were assessed: 1) Psoriasis diagnosis; 2) Cardiovascular or kidney or liver or respiratory or cerebrovascular outcomes; 3) Comparison group of individuals without psoriasis. Pooled Relative Risks (pRRs) and 95% Confidence Intervals (CIs) were calculated by using the random-effect model. Results: Fifteen observational studies with 216,348 psoriatic patients and 9,896,962 individuals from the general population were included. Psoriasis showed a greater risk of organ-based comorbidities. Compared to the general population, pRR for all organ-based comorbidities was 1.20 (95% CI 1.11–1.31) in psoriasis, and pRR was lower in mild 0.61 (95% CI 0.46–0.81) than in moderate/severe patients. pRR was 1.20 (95% CI 1.11–1.30) for cardiovascular, 1.56 (95% CI 1.20–2.04), and 1.75 (95% CI 1.33–2.29) for cerebrovascular and liver diseases, respectively. pRR for coexisting renal and cardiovascular events was 1.09 (95% CI 1.01–1.18). pRR for coexisting renal and cerebrovascular events was 1.28 (95% CI 0.99–1.66). pRR for coexisting renal and liver diseases was 1.46 (95% CI 1.10–1.94). pRR for coexisting cardiovascular and liver diseases was 1.41 (95% CI 1.11–1.80). Study limitations: There is heterogeneity. Conclusion: Psoriasis has a higher risk of single and multiple organ-based comorbidities than the general population. The present study will further improve attention to psoriasis as a systemic inflammatory disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500612&tlng=enComorbidityMeta-analysisPsoriasisRiskSystematic review |
spellingShingle | Xuemei Tang Ling Chen The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis Anais Brasileiros de Dermatologia Comorbidity Meta-analysis Psoriasis Risk Systematic review |
title | The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis |
title_full | The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis |
title_fullStr | The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis |
title_full_unstemmed | The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis |
title_short | The risk of organ-based comorbidities in psoriasis: a systematic review and meta-analysis |
title_sort | risk of organ based comorbidities in psoriasis a systematic review and meta analysis |
topic | Comorbidity Meta-analysis Psoriasis Risk Systematic review |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500612&tlng=en |
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