Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury
Cognitive deficits following traumatic brain injury (TBI) commonly include difficulties with memory, attention, and executive dysfunction. These deficits are amenable to cognitive rehabilitation, but optimally selecting rehabilitation programs for individual patients remains a challenge. Recent meth...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-10-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2010.00182/full |
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| author | Gary E Strangman Gary E Strangman Therese M O'Neil-Pirozzi Therese M O'Neil-Pirozzi Christina Supelana Richard Goldstein Douglas Katz Douglas Katz Mel B Glenn |
| author_facet | Gary E Strangman Gary E Strangman Therese M O'Neil-Pirozzi Therese M O'Neil-Pirozzi Christina Supelana Richard Goldstein Douglas Katz Douglas Katz Mel B Glenn |
| author_sort | Gary E Strangman |
| collection | DOAJ |
| description | Cognitive deficits following traumatic brain injury (TBI) commonly include difficulties with memory, attention, and executive dysfunction. These deficits are amenable to cognitive rehabilitation, but optimally selecting rehabilitation programs for individual patients remains a challenge. Recent methods for quantifying regional brain morphometry allow for automated quantification of tissue volumes in numerous distinct brain structures. We hypothesized that such quantitative structural information could help identify individuals more or less likely to benefit from memory rehabilitation. Fifty individuals with TBI of all severities who reported having memory difficulties first underwent structural MRI scanning. They then participated in a 12 session memory rehabilitation program emphasizing internal memory strategies (I-MEMS). Primary outcome measures (HVLT, RBMT) were collected at the time of the MRI scan, immediately following therapy, and again at one month post-therapy. Regional brain volumes were used to predict outcome, adjusting for standard predictors (e.g., injury severity, age, education, pretest scores). We identified several brain regions that provided significant predictions of rehabilitation outcome, including the volume of the hippocampus, the lateral prefrontal cortex, the thalamus, and several subregions of the cingulate cortex. The prediction range of regional brain volumes were in some cases nearly equal in magnitude to prediction ranges provided by pretest scores on the outcome variable. We conclude that specific cerebral networks including these regions may contribute to learning during I-MEMS rehabilitation, and suggest that morphometric measures may provide substantial predictive value for rehabilitation outcome in other cognitive interventions as well. |
| first_indexed | 2024-12-12T18:13:23Z |
| format | Article |
| id | doaj.art-22f4a5481c4f4990a768e4370ec2aab9 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-12T18:13:23Z |
| publishDate | 2010-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-22f4a5481c4f4990a768e4370ec2aab92022-12-22T00:16:19ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612010-10-01410.3389/fnhum.2010.001821728Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injuryGary E Strangman0Gary E Strangman1Therese M O'Neil-Pirozzi2Therese M O'Neil-Pirozzi3Christina Supelana4Richard Goldstein5Douglas Katz6Douglas Katz7Mel B Glenn8Harvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolNortheastern UniversityHarvard Medical SchoolHarvard Medical SchoolBoston University School of MedicineBraintree Rehabilitation HospitalHarvard Medical SchoolCognitive deficits following traumatic brain injury (TBI) commonly include difficulties with memory, attention, and executive dysfunction. These deficits are amenable to cognitive rehabilitation, but optimally selecting rehabilitation programs for individual patients remains a challenge. Recent methods for quantifying regional brain morphometry allow for automated quantification of tissue volumes in numerous distinct brain structures. We hypothesized that such quantitative structural information could help identify individuals more or less likely to benefit from memory rehabilitation. Fifty individuals with TBI of all severities who reported having memory difficulties first underwent structural MRI scanning. They then participated in a 12 session memory rehabilitation program emphasizing internal memory strategies (I-MEMS). Primary outcome measures (HVLT, RBMT) were collected at the time of the MRI scan, immediately following therapy, and again at one month post-therapy. Regional brain volumes were used to predict outcome, adjusting for standard predictors (e.g., injury severity, age, education, pretest scores). We identified several brain regions that provided significant predictions of rehabilitation outcome, including the volume of the hippocampus, the lateral prefrontal cortex, the thalamus, and several subregions of the cingulate cortex. The prediction range of regional brain volumes were in some cases nearly equal in magnitude to prediction ranges provided by pretest scores on the outcome variable. We conclude that specific cerebral networks including these regions may contribute to learning during I-MEMS rehabilitation, and suggest that morphometric measures may provide substantial predictive value for rehabilitation outcome in other cognitive interventions as well.http://journal.frontiersin.org/Journal/10.3389/fnhum.2010.00182/fullMemoryCognitive rehabilitationBehavioral NeurologyMorphometricsstructural neuroimagingbrain trauma |
| spellingShingle | Gary E Strangman Gary E Strangman Therese M O'Neil-Pirozzi Therese M O'Neil-Pirozzi Christina Supelana Richard Goldstein Douglas Katz Douglas Katz Mel B Glenn Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury Frontiers in Human Neuroscience Memory Cognitive rehabilitation Behavioral Neurology Morphometrics structural neuroimaging brain trauma |
| title | Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury |
| title_full | Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury |
| title_fullStr | Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury |
| title_full_unstemmed | Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury |
| title_short | Regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury |
| title_sort | regional brain morphometry predicts memory rehabilitation outcome after traumatic brain injury |
| topic | Memory Cognitive rehabilitation Behavioral Neurology Morphometrics structural neuroimaging brain trauma |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2010.00182/full |
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