Oral Mucosa Could Be an Infectious Target of SARS-CoV-2
The World Health Organization reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is caused by respiratory droplets and aerosols from the oral cavity of infected patients. The angiotensin-converting enzyme 2 (ACE2) is considered the host functional protein for SAR...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/9/8/1068 |
| _version_ | 1797523687211008000 |
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| author | Tatsuo Okui Yuhei Matsuda Masaaki Karino Katsumi Hideshima Takahiro Kanno |
| author_facet | Tatsuo Okui Yuhei Matsuda Masaaki Karino Katsumi Hideshima Takahiro Kanno |
| author_sort | Tatsuo Okui |
| collection | DOAJ |
| description | The World Health Organization reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is caused by respiratory droplets and aerosols from the oral cavity of infected patients. The angiotensin-converting enzyme 2 (ACE2) is considered the host functional protein for SARS-CoV-2 infection. In this article, we first revealed that the positive proportion of ACE2 expression in gingival cells collected from the gingival sulcus was increased to the same level as the tongue. Our data demonstrate that cells in the gingival sulcus may be a new entry point for the SARS-CoV-2 virus via a high expression of ACE2. In addition, we first evaluated the expression of ACE2 in various sites of the oral cavity with noninvasive, convenient liquid-based cytology. The liquid-based cytology evaluation of oral tissue may provide a novel preventive medical avenue against COVID-19. |
| first_indexed | 2024-03-10T08:46:33Z |
| format | Article |
| id | doaj.art-22f5687c48a94fbd9e92a334dcbce183 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T08:46:33Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-22f5687c48a94fbd9e92a334dcbce1832023-11-22T07:50:25ZengMDPI AGHealthcare2227-90322021-08-0198106810.3390/healthcare9081068Oral Mucosa Could Be an Infectious Target of SARS-CoV-2Tatsuo Okui0Yuhei Matsuda1Masaaki Karino2Katsumi Hideshima3Takahiro Kanno4Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo 693-8501, Shimane, JapanThe World Health Organization reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is caused by respiratory droplets and aerosols from the oral cavity of infected patients. The angiotensin-converting enzyme 2 (ACE2) is considered the host functional protein for SARS-CoV-2 infection. In this article, we first revealed that the positive proportion of ACE2 expression in gingival cells collected from the gingival sulcus was increased to the same level as the tongue. Our data demonstrate that cells in the gingival sulcus may be a new entry point for the SARS-CoV-2 virus via a high expression of ACE2. In addition, we first evaluated the expression of ACE2 in various sites of the oral cavity with noninvasive, convenient liquid-based cytology. The liquid-based cytology evaluation of oral tissue may provide a novel preventive medical avenue against COVID-19.https://www.mdpi.com/2227-9032/9/8/1068COVID-19ACE2 expression in oral regionliquid-based cytology |
| spellingShingle | Tatsuo Okui Yuhei Matsuda Masaaki Karino Katsumi Hideshima Takahiro Kanno Oral Mucosa Could Be an Infectious Target of SARS-CoV-2 Healthcare COVID-19 ACE2 expression in oral region liquid-based cytology |
| title | Oral Mucosa Could Be an Infectious Target of SARS-CoV-2 |
| title_full | Oral Mucosa Could Be an Infectious Target of SARS-CoV-2 |
| title_fullStr | Oral Mucosa Could Be an Infectious Target of SARS-CoV-2 |
| title_full_unstemmed | Oral Mucosa Could Be an Infectious Target of SARS-CoV-2 |
| title_short | Oral Mucosa Could Be an Infectious Target of SARS-CoV-2 |
| title_sort | oral mucosa could be an infectious target of sars cov 2 |
| topic | COVID-19 ACE2 expression in oral region liquid-based cytology |
| url | https://www.mdpi.com/2227-9032/9/8/1068 |
| work_keys_str_mv | AT tatsuookui oralmucosacouldbeaninfectioustargetofsarscov2 AT yuheimatsuda oralmucosacouldbeaninfectioustargetofsarscov2 AT masaakikarino oralmucosacouldbeaninfectioustargetofsarscov2 AT katsumihideshima oralmucosacouldbeaninfectioustargetofsarscov2 AT takahirokanno oralmucosacouldbeaninfectioustargetofsarscov2 |