6-Sulphated chondroitins have a positive influence on axonal regeneration.

6-Sulphated chondroitins have a positive influence on axonal regeneration.

Chondroitin sulphate proteoglycans (CSPGs) upregulated in the glial scar inhibit axon regeneration via their sulphated glycosaminoglycans (GAGs). Chondroitin 6-sulphotransferase-1 (C6ST-1) is upregulated after injury leading to an increase in 6-sulphated GAG. In this study, we ask if this increase i...

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Bibliographic Details
Main Authors: Rachel Lin, Thomas W Rosahl, Paul J Whiting, James W Fawcett, Jessica C F Kwok
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3128591?pdf=render

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