Characterizing conformational states in GPCR structures using machine learning

Abstract G protein-coupled receptors (GPCRs) play a pivotal role in signal transduction and represent attractive targets for drug development. Recent advances in structural biology have provided insights into GPCR conformational states, which are critical for understanding their signaling pathways a...

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Bibliographic Details
Main Authors: Ilya Buyanov, Petr Popov
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47698-1