Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities

Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities

Cholangiocarcinoma (CCA) features a dismal prognosis with limited treatment options. Genomic studies have unveiled several promising targets in this disease, including fibroblast growth factor receptor (FGFR) fusions and isocitrate dehydrogenase (IDH) mutations. To fully harness the potential of gen...

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Bibliographic Details
Main Authors: Alexander Scheiter, Frederik Hierl, Ingrid Winkel, Felix Keil, Margit Klier-Richter, Cédric Coulouarn, Florian Lüke, Arne Kandulski, Matthias Evert, Wolfgang Dietmaier, Diego F. Calvisi, Kirsten Utpatel
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Journal of Personalized Medicine
Subjects:
cholangiocarcinoma
β-catenin
WNT
APC
HRD
Olaparib
Online Access:https://www.mdpi.com/2075-4426/12/8/1270

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