Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement
A novel vardenafil analogue was identified in dietary supplement as an adulterant in herbal formulations. The structure of this analogue was elucidated using HRMS, NMR after extraction from the pulverized powder. It was named morphardenafil as a morpholine ring has replaced the N-ethyl piperazine ri...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023026257 |
| _version_ | 1797836867447554048 |
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| author | Chunzheng Li Xinzheng Wang Shengming Wu Junqing Zhao Junjian Fang Hui Li Yingjie Zhu Kang Zhang Jing Peng Jie Mao Weihua Li Kun He Na Wang Fangting Dong |
| author_facet | Chunzheng Li Xinzheng Wang Shengming Wu Junqing Zhao Junjian Fang Hui Li Yingjie Zhu Kang Zhang Jing Peng Jie Mao Weihua Li Kun He Na Wang Fangting Dong |
| author_sort | Chunzheng Li |
| collection | DOAJ |
| description | A novel vardenafil analogue was identified in dietary supplement as an adulterant in herbal formulations. The structure of this analogue was elucidated using HRMS, NMR after extraction from the pulverized powder. It was named morphardenafil as a morpholine ring has replaced the N-ethyl piperazine ring in vardenafil. A tablet of this dietary supplement contained about 50 mg of unspecified morphardenafil, which is 2.5 – 20-times the prescriptive dosage of Levetra, the commercial formulation of the vardenafil monohydrochloride salt in the market and probably places unwary consumers at risk for potentially serious adverse effects or drug-drug interaction (DDI). |
| first_indexed | 2024-04-09T15:16:51Z |
| format | Article |
| id | doaj.art-22fd78e5cbc34474bf1e57dd08bfcd3f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:16:51Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-22fd78e5cbc34474bf1e57dd08bfcd3f2023-04-29T14:56:41ZengElsevierHeliyon2405-84402023-04-0194e15418Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplementChunzheng Li0Xinzheng Wang1Shengming Wu2Junqing Zhao3Junjian Fang4Hui Li5Yingjie Zhu6Kang Zhang7Jing Peng8Jie Mao9Weihua Li10Kun He11Na Wang12Fangting Dong13National Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaNational Center of Biomedical Analysis, Beijing, 100039, ChinaCorresponding author. .(N. WANG).; National Center of Biomedical Analysis, Beijing, 100039, ChinaCorresponding author. (F. DONG).; National Center of Biomedical Analysis, Beijing, 100039, ChinaA novel vardenafil analogue was identified in dietary supplement as an adulterant in herbal formulations. The structure of this analogue was elucidated using HRMS, NMR after extraction from the pulverized powder. It was named morphardenafil as a morpholine ring has replaced the N-ethyl piperazine ring in vardenafil. A tablet of this dietary supplement contained about 50 mg of unspecified morphardenafil, which is 2.5 – 20-times the prescriptive dosage of Levetra, the commercial formulation of the vardenafil monohydrochloride salt in the market and probably places unwary consumers at risk for potentially serious adverse effects or drug-drug interaction (DDI).http://www.sciencedirect.com/science/article/pii/S2405844023026257Vardenafil analoguePDE-5 inhibitorDietary supplementAdulterantsMorpholine ringHRMS |
| spellingShingle | Chunzheng Li Xinzheng Wang Shengming Wu Junqing Zhao Junjian Fang Hui Li Yingjie Zhu Kang Zhang Jing Peng Jie Mao Weihua Li Kun He Na Wang Fangting Dong Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement Heliyon Vardenafil analogue PDE-5 inhibitor Dietary supplement Adulterants Morpholine ring HRMS |
| title | Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement |
| title_full | Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement |
| title_fullStr | Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement |
| title_full_unstemmed | Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement |
| title_short | Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement |
| title_sort | separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement |
| topic | Vardenafil analogue PDE-5 inhibitor Dietary supplement Adulterants Morpholine ring HRMS |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023026257 |
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