Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click Chemistry
Near-infrared dyes were developed to be contrast agents due to their ability to improve the productivity of photoacoustic (PA) imaging and photothermal therapy (PTT) treatments. During the article, we described in detail the PA and PT effects of a category of organic molecules. F<sub>4</sub...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/7/2329 |
| _version_ | 1797438298655817728 |
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| author | Wenqing Zhu Zongcheng Miao Yaqin Chu Liaoliao Li Lei Wang Dong Wang |
| author_facet | Wenqing Zhu Zongcheng Miao Yaqin Chu Liaoliao Li Lei Wang Dong Wang |
| author_sort | Wenqing Zhu |
| collection | DOAJ |
| description | Near-infrared dyes were developed to be contrast agents due to their ability to improve the productivity of photoacoustic (PA) imaging and photothermal therapy (PTT) treatments. During the article, we described in detail the PA and PT effects of a category of organic molecules. F<sub>4</sub>-TCNQ could potentially cause a red-shift in the peak PA intensity. The results show that the PTT intensity of the near-infrared dyes with phenyl groups were higher than near-infrared dyes with thiophene groups. We also investigated the photodynamic treatment effect of C1b to demonstrate that these dyes are highly desirable in biochemistry. The high photoacoustic intensity of the organic molecules and the good yield of reactive oxygen species could indicate that these dyes have good potential for a wide range of imaging applications. Finally, we embedded the dye (C1b) in a liposomal hydrophobic phospholipid bilayer (C1b⊂L) to facilitate the application of hydrophobic dyes in biomedical applications, which can be absorbed by cells with good compatible and high stability for the imaging of cellular PA. |
| first_indexed | 2024-03-09T11:35:39Z |
| format | Article |
| id | doaj.art-22fdd48e8a1a428e8b42d08e60c09558 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:35:39Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-22fdd48e8a1a428e8b42d08e60c095582023-11-30T23:42:45ZengMDPI AGMolecules1420-30492022-04-01277232910.3390/molecules27072329Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click ChemistryWenqing Zhu0Zongcheng Miao1Yaqin Chu2Liaoliao Li3Lei Wang4Dong Wang5School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, ChinaSchool of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, ChinaSchool of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, ChinaSchool of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, ChinaKey Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi’an 710021, ChinaSchool of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, ChinaNear-infrared dyes were developed to be contrast agents due to their ability to improve the productivity of photoacoustic (PA) imaging and photothermal therapy (PTT) treatments. During the article, we described in detail the PA and PT effects of a category of organic molecules. F<sub>4</sub>-TCNQ could potentially cause a red-shift in the peak PA intensity. The results show that the PTT intensity of the near-infrared dyes with phenyl groups were higher than near-infrared dyes with thiophene groups. We also investigated the photodynamic treatment effect of C1b to demonstrate that these dyes are highly desirable in biochemistry. The high photoacoustic intensity of the organic molecules and the good yield of reactive oxygen species could indicate that these dyes have good potential for a wide range of imaging applications. Finally, we embedded the dye (C1b) in a liposomal hydrophobic phospholipid bilayer (C1b⊂L) to facilitate the application of hydrophobic dyes in biomedical applications, which can be absorbed by cells with good compatible and high stability for the imaging of cellular PA.https://www.mdpi.com/1420-3049/27/7/2329near-infraredphotoacoustic imagingphotothermal treatmentphotodynamic therapy |
| spellingShingle | Wenqing Zhu Zongcheng Miao Yaqin Chu Liaoliao Li Lei Wang Dong Wang Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click Chemistry Molecules near-infrared photoacoustic imaging photothermal treatment photodynamic therapy |
| title | Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click Chemistry |
| title_full | Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click Chemistry |
| title_fullStr | Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click Chemistry |
| title_full_unstemmed | Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click Chemistry |
| title_short | Photoacoustic Effect of Near-Infrared Absorbing Organic Molecules via Click Chemistry |
| title_sort | photoacoustic effect of near infrared absorbing organic molecules via click chemistry |
| topic | near-infrared photoacoustic imaging photothermal treatment photodynamic therapy |
| url | https://www.mdpi.com/1420-3049/27/7/2329 |
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