THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS
Multiple myeloma (MM) is a malignant blood cancer characterized by proliferation of plasma cells in bone marrow that is mainly composed by inflammatory cells. A prognostic effect can be assessed as consequence of alterations in peripheral blood leukocytes and the ratio between blood cells have been...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923009355 |
| _version_ | 1797654882049589248 |
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| author | LF Corral L Kowalczuk C Bundchen SC Wagner LN Rotta |
| author_facet | LF Corral L Kowalczuk C Bundchen SC Wagner LN Rotta |
| author_sort | LF Corral |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a malignant blood cancer characterized by proliferation of plasma cells in bone marrow that is mainly composed by inflammatory cells. A prognostic effect can be assessed as consequence of alterations in peripheral blood leukocytes and the ratio between blood cells have been pointed as prognosis marker of several tumors. Objective: To evaluate the prognostic significance of lactate dehydrogenase (LDH) and the ratios between neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR) and platelet-to-lymphocyte (PLR), and associations between them, on progression-free survival (PFS) and overall survival (OS) in MM. Methods: We retrospectively analyzed 117 data of newly MM patients diagnosed between Jun/2008-Dec/2018 from two hospitals in Porto Alegre/RS/Brazil. The results of LDH pretreatment (3 to 7 days) and absolute values of leukocytes and platelet were collected to calculate NLR, MLR and PLR. Area under curve (ROC) determined the cut off value associated to death. Univariate and multivariate Cox proportional hazard analyses assessed the relationship of the MRL and LDH to PFS and OS. Results: MLR ≥0.43 and LDH ≥292.5 were associated with shorter OS (40.7 vs 80.4 months; p < 0.0001; 43.8 vs 85.7 months; p = 0.004) and the multivariate analysis showed that these RML and LDH values are independent prognostic factor for predicting OS (p = 0.033 and 0.008, respectively). The association of higher RML and LDH values present a RR 3.61 to death (p = 0.02). Conclusion: LDH and MLR can predict clinical outcomes in newly diagnosed MM patients and may serve as a simple and cost-effective prognostic marker in the routine practice. |
| first_indexed | 2024-03-11T17:07:04Z |
| format | Article |
| id | doaj.art-22fed154bafe4dfcabb68a3a45938339 |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-03-11T17:07:04Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-22fed154bafe4dfcabb68a3a459383392023-10-20T06:43:30ZengElsevierHematology, Transfusion and Cell Therapy2531-13792023-10-0145S401THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTSLF Corral0L Kowalczuk1C Bundchen2SC Wagner3LN Rotta4Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, BrazilUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, BrazilUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, BrazilUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, BrazilUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, BrazilMultiple myeloma (MM) is a malignant blood cancer characterized by proliferation of plasma cells in bone marrow that is mainly composed by inflammatory cells. A prognostic effect can be assessed as consequence of alterations in peripheral blood leukocytes and the ratio between blood cells have been pointed as prognosis marker of several tumors. Objective: To evaluate the prognostic significance of lactate dehydrogenase (LDH) and the ratios between neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR) and platelet-to-lymphocyte (PLR), and associations between them, on progression-free survival (PFS) and overall survival (OS) in MM. Methods: We retrospectively analyzed 117 data of newly MM patients diagnosed between Jun/2008-Dec/2018 from two hospitals in Porto Alegre/RS/Brazil. The results of LDH pretreatment (3 to 7 days) and absolute values of leukocytes and platelet were collected to calculate NLR, MLR and PLR. Area under curve (ROC) determined the cut off value associated to death. Univariate and multivariate Cox proportional hazard analyses assessed the relationship of the MRL and LDH to PFS and OS. Results: MLR ≥0.43 and LDH ≥292.5 were associated with shorter OS (40.7 vs 80.4 months; p < 0.0001; 43.8 vs 85.7 months; p = 0.004) and the multivariate analysis showed that these RML and LDH values are independent prognostic factor for predicting OS (p = 0.033 and 0.008, respectively). The association of higher RML and LDH values present a RR 3.61 to death (p = 0.02). Conclusion: LDH and MLR can predict clinical outcomes in newly diagnosed MM patients and may serve as a simple and cost-effective prognostic marker in the routine practice.http://www.sciencedirect.com/science/article/pii/S2531137923009355 |
| spellingShingle | LF Corral L Kowalczuk C Bundchen SC Wagner LN Rotta THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS Hematology, Transfusion and Cell Therapy |
| title | THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS |
| title_full | THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS |
| title_fullStr | THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS |
| title_full_unstemmed | THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS |
| title_short | THE PROGNOSTIC VALUE OF ELEVATED MONOCYTE-TO-LYMPHOCYTE RATIO AND LACTATE DEHYDROGENASE IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS |
| title_sort | prognostic value of elevated monocyte to lymphocyte ratio and lactate dehydrogenase in newly diagnosed multiple myeloma patients |
| url | http://www.sciencedirect.com/science/article/pii/S2531137923009355 |
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